How to Bet Every Sweet 16 Game in 2019 NCAA Tournament

The Sweet 16 is here, and it’s a sweet one indeed for fans of college basketball betting: four No. 1 seeds, four No. 2 seeds, four No. 3 seeds and a pair of No. 4s.
It’s been a decade at least since March Madness has seen regional semifinals this loaded, the product of early rounds that produced a number of close, entertaining games but not many straight-up upsets.
For basketball fans, that’s a good thing — Thursday and Friday present some matchups worthy of the Final Four and a great two days of watching March Madness.
But for college basketball betting fans, slates of power teams facing off against one another lead to narrow point spreads and difficult decisions.To help, here’s a betting guide to what could be the best round of this tournament.
Thursday’s Sweet 16 Games

No. 1 Gonzaga (-7) vs. No. 4 Florida State
For all the hype around Duke and Zion Williamson and all the attention paid to the ACC producing three No. 1 seeds, no team in this tournament has looked better through two rounds than the Zags, who have been unchallenged to this point.
In a guard-oriented game, Gonzaga presents a tough matchup with its deep frontcourt of Rui Hachimura, Brandon Clarke and Killian Tillie, who thrive in an offense that moves at a breakneck pace.
Florida State has failed to cover in seven of its last 10, but tends to play up and down to competition, and the long, athletic Seminoles have the size and personnel to keep this close. Pick: Florida State
No. 2 Tennessee (-1) vs. No. 3 Purdue
There was plenty of celebrating in the Tennessee locker room on Sunday, while everyone else was wondering how such a veteran team can play a white-knuckler against Colgate and then nearly blow a huge lead against mediocre Iowa.
The Vols showed a real weakness for defending the 3-point shot in their close call against the Raiders, a deficiency that could prove lethal against a Purdue team that can fill it up from deep.
And then there’s Boilermaker star Carsen Edwards, who struck for 26 against Old Dominion and 42 against Villanova, and has perhaps been the best individual player of the tournament so far. We see the same Vols defense as the opening two rounds, watch out. Pick: Purdue
No. 2 Michigan (-2) vs. No. 3 Texas Tech
There are no style points when it comes to Texas Tech, which simply grinds opponents into submission behind one of the best defenses in the game. That approach helped the Red Raiders somewhat easily dispatch two upset-minded darlings in Northern Kentucky and Buffalo, and cover 10 of its last 12.
But nowhere in that span has Chris Beard’s team faced an opponent as good as the Wolverines, who feature elite on-the-ball defenders and quality size inside.
Michigan plays defense every bit as good as Texas Tech does — the Wolverines are second, the Raiders fourth nationally in scoring defense — but do it with a more skilled lineup that’s produced two easy NCAA wins and covers in eight of its last 11. Pick: Michigan
No. 1 Virginia (-8) vs. No. 12 Oregon
They’ve been helped by a good draw and an upset on their side of the bracket, but the Ducks have earned it by winning 10 straight to become the only real surprise of the Sweet 16.
That success has translated against the spread, where Oregon has also covered in every game of its winning streak. Virginia has hardly looked bulletproof, falling behind big to No. 16 seed Gardner-Webb before rallying to stave off panic, and failing to cover three of its last five.
But Oregon’s defensive, somewhat plodding style plays right into the hands of a Virginia squad that commands tempo, and it’s hard to envision the Ducks pushing the Cavaliers out of their comfort zone.
Matchups matter, and this is a case of two teams that play in similar ways, and one of them that does it much better. Pick: Virginia
Thursday’s NCAA Sweet 16 Odds
Moneyline | Total | Spread |
---|---|---|
1 Gonzaga (1.27) v 4 FSU (3.60) | O/U 147.5 | GON -7 |
2 Tennessee (1.83) v 3 Purdue (1.95) | O/U 146.5 | TEN -1 |
2 Michigan (1.71) v 3 Texas Tech (2.10) | O/U 125 | MICH -2 |
1 Virginia (1.21) v 12 Oregon (4.10) | O/U 118 | UVA -8 |
Friday’s Sweet 16 Games

No. 2 Michigan State (-5.5) vs. No. 3 LSU
No head coach? No problem for the cardiac Tigers, who continue to win close games even with Will Wade still suspended by the school for his alleged role in the game’s corruption scandal.
Going to the final minute against Yale and needing a last-second shot to beat Maryland wouldn’t seem to inspire confidence against Michigan State, which has won seven straight and 11 of its last 12, and has covered 10 of its last 14.
But LSU’s backcourt duo of Tremont Waters and Skylar Mays matches up well with Michigan State’s Cassius Winston and Matt McQuaid, and nobody’s beaten the Tigers by more than five points since December. Pick: LSU
No. 1 North Carolina (-5) vs. No. 5 Auburn
Auburn has elite talent, and the Tigers seem to finally be putting it all together with 10 straight wins capped by an absolute hammering of Kansas. Now comes the challenge of keeping it going against the Tar Heels, who are right up there with Gonzaga as far as the best team in the tournament so far.
And yet, the Auburn that lost to a host of lesser lights in the regular season still rears its head from time to time, as it did in the final moments in the opening round against New Mexico State.
North Carolina has been far more consistent, covering in eight of its last 11. The Tigers have outstanding players; the Heels have the better team. Pick: UNC
No. 1 Duke (-7) vs. No. 4 Virginia Tech
So, what to make of the No. 1 overall seed nearly meeting its end to Central Florida in the second round? You rely almost exclusively on freshmen in the NCAA Tournament, you’re going to endure some heart-in-the-throat moments like we saw Sunday afternoon.
UCF tried a strategy of making Duke players other than Zion, R.J. Barrett and Cam Reddish beat them, and none of the other Blue Devils were able to step up and make shots.
Expect other teams to notice — especially the Hokies, who are as healthy as they’ve been in some time, and beat the Zion-less Devils last month. Duke has failed to cover in 10 of its last 13, and the number here seems too big against a fellow ACC team that will know its opponent all too well. Pick: Virginia Tech
No. 2 Kentucky (-2.5) vs. No. 3 Houston
The Wildcats won and covered in each of the first two rounds without injured forward P.J. Washington, who’s suffering from what’s being called a sprained foot. And yet, it seems more serious, given Kentucky’s best player has his left foot in a hard cast and told CBS he “heard a pop” before going down.
Without him, a short Kentucky rotation gets even shorter, and the Wildcats rely further on their cast of excellent, defensive-minded guards.
Houston has a ridiculous 33-3 record and a phenomenal guard in Corey Davis Jr., but not necessarily the kind of inside game that can exploit Washington’s absence inside. Pick: Kentucky
Friday’s NCAA Sweet 16 Odds
Moneyline | Total | Spread |
---|---|---|
2 Michigan State (1.35) v 3 LSU (3.10) | O/U 149 | MSU -5.5 |
1 North Carolina (1.43) v 5 Auburn (2.70) | O/U 163 | UNC -5 |
1 Duke (1.28) v 4 Va. Tech (3.50) | O/U 144.5 | DUKE -7 |
2 Kentucky (1.64) v 3 Houston (2.20) | O/U 135.5 | KEN -2.5 |
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