Everton vs Liverpool Prediction, Premier League Betting Picks & EPL Odds

Everton vs Liverpool Predictions

• Liverpool to win & under 3.5 goals (+125 Betway)
• Abdoulaye Doucoure to be shown a card (+255 BetRivers)

Premier League games don't come much bigger than the Merseyside derby, but there's far more at stake than local bragging rights this time in Wednesday's showdown between Everton and Liverpool (2.30pm, FUBO TV).

The 245th derby will be the last to be played at Everton's current home Goodison Park, with the Toffees set to move into a new stadium for the 2025/26 season.

Everton will be desperate to mark the occasion with a win, not only as a tribute to their home for the past 133 years but also to dent Liverpool's title aspirations on their final visit.

Not only that, a win for David Moyes's side will move them 12 points clear of the EPL's relegation zone.

However, betting sites expect Liverpool to come out on top in what could turn out to be a crucial game in the title race as the current league leaders look to extend their advantage to nine points.

A response is expected from the Reds following their shock loss to second-tier strugglers Plymouth Arygle in the FA Cup last weekend and it's tough to imagine Arne Slot's men losing two games in a row.

Everton vs Liverpool Betting Picks: Reds To Pass Goodison Test

Slot took the decision to leave the likes of Mohamed Salah, Virgil van Dijk, Ryan Gravenberch and more at home of the trip to Plymouth with one eye on Wednesday's game.

It was a move that backfired as they crashed out of the FA Cup. However, the league is the priority and this is Liverpool's game in hand on the chasing pack in the title race. 

Opening up a nine-point lead with 14 matches to play would not only give the Anfield outfit a huge lead but also deal quite a psychological blow to second-placed Arsenal.

Soccer betting sites are strongly behind the Reds, who are a best-price of -227, while you can get +700 on an Everton win.

A victory for the home side wouldn't come as that big of a surprise given their upturn in form since Moyes returned as head coach, the former West Ham boss winning three of his first five games in charge.

Everton also won the last derby meeting 2-0 last April when Liverpool were also going for the title, albeit the Reds weren't as strong as they have been this season.

The loss to Plymouth was only Liverpool's third in all competitions under Slot and they are currently 19 games unbeaten in the Premier League.

And, while Slot can bring back the big guns having rested them at the weekend, Moyes has fewer options at his disposal with as many as seven players set to miss this game, including Dwight McNeil and Dominic Calvert-Lewin.

Everton were struggling to score goals before they lost Calvert-Lewin to injury and their best hope of getting a positive result may rest on a solid defense that's kept five shut outs in 12 home league games this season.

Recent Merseyside derby games have tended to be low-scoring. Only five of the last 20 games have featured four or more goals, while one team has failed to score in six of the last seven encounters.

Games at Goodison have tended to end all square, but Liverpool know how big a win is here for their season and their extra quality gives them an edge.

You can find Liverpool to win and under 3.5 goals paired together on several on betting apps, with Betway offering +125 on a low-scoring away win.

Everton vs Liverpool Pick 1: Liverpool to win & under 3.5 goals (+125 Betway)

Everton vs Liverpool Picks: Doucoure a Card Candidate

No Premier League fixture has produced more red cards than the 23 shown in Merseyside derbies and referee Michael Oliver has a history of going to his pocket at Goodison Park.

The last time Oliver officiated a Merseyside derby, he brandished six cards, including one red, in a 2-2 draw in 2020.

There are a few candidates who could go into Oliver's notebook on Wednesday when studying the card markets on new betting sites, chief among them is Everton midfielder Abdoulaye Doucoure.

He's only got two cautions this season, but both have come since the start of 2025, and he could probably have a few more yellows to his name as the Everton player who's committed the most fouls in the EPL this term.

Doucoure has been shown a yellow card in two of his last four appearances against Liverpool and on a night when Everton will see less of the ball, the Mali midfielder is likely to be busy trying to unsettle the Reds passing rhythm.

Everton vs Liverpool Pick 2: Abdoulaye Doucoure to be shown a card (+255 BetRivers)