Premier League Betting Advice for Opening Weekend

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Premier League Betting Advice for Opening Weekend
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We enter the 2022-23 Premier League season with so many questions to ask. 

Will Liverpool get closer to Manchester City? 

Which London team will finish the highest? 

Will Manchester United get back to its best? 

Ultimately, we’re in for a thrilling 10 months of action.

We’ve put together our Premier League betting advice for the opening weekend.  

Game of the Week

Brighton +480 at Manchester United -165

Man United enters this season officially a decade on since it last won the EPL title. With this comes a new manager, Erik ten Hag, a few new players, and a boatload of questions surrounding the club. However, United is coming into the new season after a preseason of winning three games, losing one and tied two.

We’ve chosen this as the game of the week for the simple idea that this is a new era at one of the biggest soccer clubs in the world and anything could happen. United is the favorite to win, however, and we think it’ll get the job done quite comfortably at Old Trafford.

Brighton & Hove Albion is also coming into this one off the back of losing its star player, Marc Cucurella, and this just plays the game into United’s hands even more.

United to beat Brighton 3-0 is +1200 with FanDuel.

Best Bet of the Week

Chelsea -165 at Everton +470

Former Chelsea head coach and its all-time top goalscorer, Frank Lampard, will go against his old team once when his Everton team welcomes Chelsea to Goodison Park. 

Everton is coming into this one after its worst season in Premier League history. Now, a few months on from almost getting relegated, it has also lost its best player, Richarlison, and it doesn’t feel like the Toffees are going to be able to get that much better this season.

Chelsea, however, is coming into the new season with three excellent transfers: Raheem Sterling, Cucurella, and Kalidou Koulibaly. It shows clear improvement on a side that already finished third last year, and we think the Blues could ease past Everton in this game.  

Chelsea to Beat Everton and Over 2.5 Goals is +170 with DraftKings.

Underdog Bet of the Week

Nottingham Forest

It’s the first Premier League season for Nottingham Forest in 23 years. It has one of the toughest opening games out there to deal with, however, as it travels to St. James’ Park to meet with Newcastle United.

Surprisingly, despite the fact Newcastle is the wealthiest club in world soccer right now, it's Nottingham that completed the most astute transfers out of the two teams. Nottingham added the likes of Jesse Lingard, Dean Henderson and Neco Williams to its roster for the new season and we think they’re being overlooked too easily in this game.

We’re picking Nottingham as our underdog bet of the week, as it could spring an upset in the North East of England this weekend with so much hope and confidence running through its team right now.

Nottingham to beat Newcastle 2-1 this weekend is +1700 with DraftKings.

Player to Watch This Week

Harry Kane, Tottenham Hotspur

Harry Kane is entering this season at the highest odds he has been at in many years to win the Golden Boot, and this only comes because the Premier League sees Erling Haaland, Mohamed Salah and Darwin Nunez play too.

However, Tottenham Hotspur has gotten even better this summer, and it has arguably had the best transfer business of any Premier League team so far. What’s more, with manager Antonio Conte having a full preseason to work with his players, we expect Kane to get right back to his goalscoring best.

The England captain meets with Southampton this weekend in the EPL. Kane already has 11 goals in 14 games against Southampton, along with a further six assists. It’s one of Kane’s best teams to play against in terms of goal contributions, so while all the attention is on Haaland and Nunez this weekend, do not forget the Tottenham striker’s extraordinary record in this fixture.

Kane To Score And Tottenham To Win 2-0, 2-1 Or 3-1 is +380 with Caesars. 

Hardest Game to Call

Wolves +220 at Leeds United +130

After two very underwhelming seasons in the Premier League, Wolves and Leeds United will meet at Elland Road with so much to prove this campaign. Wolves finished 10th last season as it registered one of its worst years in the Premier League since coming back into the league in 2018.

Leeds avoided relegation back into the Championship by the skin of its teeth last season, as it survived in the EPL by just three points. Now, with barely any good news in the transfer market for either team, this game has become quite tough to call. 

What’s more, Wolves was one of the best defensive sides in the league last year with only 43 goals conceded, just as Leeds let in 79 goals and continued to be an attacking threat too.

This game could be won by either team, and because it’s so tough to call, we’re going for a tie.

A tie in this game is +225 with PointsBet.

Throw Ins

These are some other bets worth a look on this week’s schedule:

  • Nunez and Salah to score 1+ goal and Liverpool to beat Fulham is +240 at BetMGM.
  • Allan Saint-Maximin to assist a goal against Nottingham is +260 at PointsBet.
  • Erling Haaland to score first is +220 at FanDuel.
  • Harvey Barnes to have 2 or more shots on target is +200 at DraftKings.
  • A tie between Aston Villa and Bournemouth is +235 at Caesars.

This Week’s Schedule with Moneylines (All Times Eastern)


  • Arsenal (-115) at Crystal Palace (+340), 3 p.m.


  • Liverpool (-380) at Fulham (+1000), 7:30 a.m.
  • Aston Villa (-105) at Bournemouth (+280), 10 a.m.
  • Wolves (+220) at Leeds United (+130), 10 a.m.
  • Nottingham Forest (+470) at Newcastle (-155), 10 a.m.
  • Southampton (+800) at Tottenham (-290) 10 a.m.
  • Chelsea (-165) at Everton (+470), 12:30 p.m.


  • Brighton (+480) at Manchester United (-165), 9 a.m.
  • Brentford (+270) at Leicester (+100), 9 a.m.
  • Manchester City (-280) at West Ham (+650), 11:30 a.m.
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