NFL Week 5 Predictions, Odds & NFL Picks for All NFL Games in Week 5

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NFL Week 5 Predictions, Odds & NFL Picks for All NFL Games in Week 5
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NFL Picks & NFL Best Bets for Week 5

The NFL regular season continues with Week 5 as teams attempt to position themselves at the top of the standings. Teams off to slow starts such as the Carolina Panthers and Cincinnati Bengals will attempt to turn their seasons around, while Week 5 is highlighted by the Sunday Night showdown between the Dallas Cowboys and San Francisco 49ers. 

To get you ready for the NFL betting season, we’re providing you with some of our NFL best bets and picks. We’re also providing showing you the new sportsbook promotions, best bets and bonuses offered by our top sportsbooks featured on this page. Take advantage of these bonus bets and generous bonuses to help you solidify your NFL betting bankroll. 

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Read our detailed analysis and NFL betting picks, giving you the information necessary to make valuable bets and have a fun viewing experience. Become informed, hone your betting skills and get ready to prepare to place the NFL picks that will give you a chance to earn more winners. 

⭐ Check Out the Best NFL Betting Trends for Week 5! ⭐ 

Chicago Bears vs. Washington Commanders NFL Picks & Odds

Terry McLaurin has been the leading receiver for the Commanders this season, recording 26 catches for 212 yards. We are going to target a McLaurin prop for Thursday's matchup with the Bears. 

Place Your NFL Picks on the Bears vs. Commanders Week 5 Matchup NOW!

We are going with McLaurin over 58.5 receiving yards (-114) at FanDuel. He's coming off his best game against the Eagles with eight catches on 10 targets for 86 yards. McLaurin has also gotten at least six targets in each of his last three games. 

Considering the Bears rank as one of the worst pass defenses in the league, we like McLaurin's over on his receiving yardage prop. 

⭐ My Best Bet: Terry McLaurin Over 58.5 Receiving Yards (-114) at FanDuel

Houston Texans vs. Atlanta Falcons NFL Picks & Odds

Houston has found life after an 0-2 start, winning in back-to-back weeks over the Pittsburgh Steelers and Jacksonville Jaguars. Much of the team's success can be traced to the strong start from rookie quarterback C.J. Stroud. In four games, stroud has thrown for 1,212 yards, which ranks fourth in the league. He also has six touchdowns and zero interceptions. It's been an impressive showing from the rookie.

Place Your NFL Picks on the Texans vs. Falcons Week 5 Matchup NOW!

Meanwhile, Atlanta's young quarterback, Desmond Ridder, has struggled. He's coming off a 23-7 loss to the Jaguars where he completed just 19 of 31 passes for 191 yards and two interceptions. Ridder wasn't much better in Week 3 during the 20-6 loss to the Detroit Lions, throwing for just 201 yards and no touchdowns. With Atlanta scoring just 13 points int eh last two weeks and the Texans recording dominant wins over two teams prognosticators figured to be in the playoff chase, we feel confident in taking the Texans as small underdogs.

⭐ My Best Bet: Texans +2 (-110) at BetMGM

Carolina Panthers at Detroit Lions NFL Picks & Odds

There's not much to get excited about with the 0-4 Carolina Panthers. Carolina hasn't even been that competitive in a lot of games and is just 0-2-1 against the spread this season, with the lone push coming on a backdoor cover in a 20-17 loss to the New Orleans Saints that wasn't even that close. 

No. 1 pick Bryce Young has struggled in his rookie season, too. The Carolina quarterback missed one game due to injury but returned for the Week 4 loss to the Minnesota Vikings. Young has struggled this season and ranks 33rd out of 34 quarterbacks in yards per pass attempt at 4.9. He has just two touchdowns and two interceptions. Just last week, Carolina's defense scored more points than the offense with a 99-yard interception return for a touchdown by Sam Franklin Jr., while the offense just managed two field goals.

Place Your NFL Picks on the Panthers vs. Lions Week 5 Matchup NOW!

We're going to back the Lions here, who are 3-1 against the spread this season. Detroit has dominated its last two opponents, beating the Falcons 20-6 and the rival Green Bay Packers 34-20 in a game it led 27-3 at halftime. With how dominant the Lions have been rolling and the Panthers' continued offensive struggles, we expect a big Lions victory in Detroit.

⭐ My Best Bet: Lions -9.5 (-110) at BetMGM

Tennessee Titans vs. Indianapolis Colts NFL Week 5 Predictions

It's been an interesting season for the Tennessee Titans. They've won a close game, beating the Los Angeles Chargers in overtime, 27-24, and also lost a tight one, falling to the New Orleans Saints 16-15. Then there were the blowouts. Tennessee is coming off a 27-3 win over the Cincinnati Bengals in Week 4, but also lost to the Cleveland Browns by the same score in Week 3. 

Place Your NFL Best Bets on the Titans vs. Colts Week 5 Matchup NOW!

Meanwhile, the Indianapolis Colts are also 2-2 and have played two consecutive drama-filled games of their own, beating the Baltimore Ravens in overtime 22-19 before falling to the Los Angeles Rams 29-23. But those two games highlighted a weakness for the Colts. Baltimore gained 186 yards on the ground, averaging 5 yards per carry, while the Rams finished with 164 yards and averaged 4.6 yards per attempt. 

Tennessee is at its best when it can establish the run, as it was able to do so in the win over the Bengals. The Titans ran for 173 yards (5.2) and were led by Derrick Henry gaining 122 yards and a touchdown. We like the Titans in this matchup and expect Henry to have a strong game against the Colts' porous run defense.

⭐ My Best Bet: Titans Moneyline (-110) FanDuel

Jacksonville Jaguars vs. Buffalo Bills Week 5 NFL Picks

The Buffalo Bills have turned into one of the most dominant teams in the NFL following the Week 1 loss to the New York Jets. Buffalo has won its last three games by an average of 30 points, including a 48-20 win over the previously unbeaten Miami Dolphins. But we're going to go the other way in this weekend's London game. 

Place Your NFL Best Bets on the Jaguars vs. Bills Week 5 Matchup NOW!

Buffalo will be at a disadvantage considering Jacksonville is already acclimated to the time change and conditions in London after beating the Atlanta Falcons 23-7 in London on Sunday. Jacksonville's defense was dominant, allowing just 287 yards and recording four sacks and forcing three turnovers. It's fair to wonder question if the Bills will be able to get up mentally and physically for a London game after the marquee matchup against the division-rival Dolphins. 

With these factors going against Buffalo, we will take the Jaguars. 

⭐ My Best Bet: Jaguars +5.5 (-110) at bet365

New Orleans Saints vs. New England Patriots Week 5 NFL Picks

The Saints offense has stalled out. After leading the Green Bay Packers 17-0 in Week 3, the Saints have scored just nine points in their last six quarters, losing 18-17 to Green Bay and falling 26-9 to the Tampa Bay Buccaneers. Derek Carr's status was questionable going into Week 4 and he didn't play well, completing just 23 of 37 passes for 127 yards. 

Place Your NFL Best Bets on the Saints vs. Patriots Week 5 Matchup NOW!

The Patriots have struggled in their own right and are coming off a 38-3 beatdown to the Dallas Cowboys. Mac Jones was bad, throwing two interceptions and only throwing for 150 yards while converting on 12 of 21 passes. Jones was eventually pulled from the game. 

With two offenses struggling this bad, we like the under in this game despite it being at a low total of 40. The last three Patriots games have gone under, while all four Saints games have gone under this season.

⭐ My Best Bet: Under 40 (-110) at BetMGM

Baltimore Ravens vs. Pittsburgh Steelers Week 5 NFL Picks

With how bad the Pittsburgh Steelers offense has been, we have no choice but to fade them. Pittsburgh was just blown out 30-6 by the Houston Texans in a game where the offense gained just 225 yards, gave up three sacks and committed two turnovers. That's two games now where the Steelers offense has looked terrible, including the 30-7 loss to the San Francisco 49ers in Week 1. 

Place Your NFL Picks on the Ravens vs. Steelers Week 5 Matchup NOW!

Kenny Pickett managed to throw for just 114 yards on 15 of 23 pass attempts. Given how the Steelers have yet to develop any offensive consistency this season, we're going to take the Ravens. Baltimore's defense was dominant against an inept Cleveland offense in Week 4's 28-3 win over the Browns.

⭐ My Best Bet: Ravens -4 (-110) FanDuel

New York Giants vs. Miami Dolphins Week 5 NFL Picks

This is an ideal bounce-back spot for a Miami Dolphins team that was blown out by the Buffalo Bills 48-20. Miami gets an ideal matchup against a New York Giants team that was embarrassed on Monday Night Football, losing 24-3 to the Seattle Seahawks. The Giants' issues don't appear to be able to be fixed in just a week. 

Place Your NFL Best Bets on the Giants vs. Dolphins Week 5 Matchup NOW!

New York surrendered 11 sacks, with Daniel Jones routinely running for his life whenever he dropped back to pass. With the Giants line dealing with injuries and the inability to block anyone, not even the chance running back Saquon Barkley returns could be enough for us to want to back New York based off what we saw last week. 

⭐ My Best Bet: Dolphins -11 (-110) at Caesars

Cincinnati Bengals vs. Arizona Cardinals Week 5 NFL Picks

It's been a trying season for the Cincinnati Bengals offense. The offense has been held to just three points in two games this season, including last week's 27-3 loss to the Tennessee Titans. Cincinnati generated just 211 yards, was sacked three times and Joe Burrow threw an interception. Burrow completed just 20 of 30 passes for 165 yards as he and the rest of the Bengals lack the form from the Super Bowl run two seasons ago. 

Place Your NFL Best Bets on the Bengals vs. Cardinals Week 5 Matchup NOW!

Burrow ranks last out of all 34 quarterbacks in passing yards per attempt at 4.8. The Bengals' pass game is nonexistent this season and remains in a place where we can't suggest a bet on Cincinnati as long as its offense continues to struggle. We'll go with the underdog Arizona Cardinals, who have a signature win at home already over the Dallas Cowboys.

⭐ My Best Bet: Cardinals +3 (-110) at bet365

Philadelphia Eagles vs. Los Angeles Rams Week 5 NFL Picks

Despite low expectations, the Los Angeles Rams have started the season off solidly with a 2-2 record despite not having Cooper Kupp, who has yet to debut this season as he continues to nurse a hamstring injury. The Rams have found offensive success on the ground, gaining 164 yards and two touchdowns in the 29-23 overtime win over the Indianapolis Colts. 

Place Your NFL Best Bets on the Eagles vs. Rams Week 5 Matchup NOW!

With the Rams getting +4.5 points at home against the Eagles, we like Los Angeles to cover considering the balance on offense. Matthew Stafford completed 27 of 40 passes for 319 yards in the Rams' win over the Colts, and defensive lineman Aaron Donald remains one of the game's elite defensive players. Philadelphia's defense was just exposed in a 34-31 overtime win over the Washington Commanders, and given the Rams' balance, we like Los Angeles at home.

⭐ My Best Bet: Rams +4.5 (-110) at BetMGM

New York Jets vs. Denver Broncos Week 5 NFL Picks

We may have seen New York Jets quarterback Zach Wilson turn a corner during Sunday's 23-20 loss to the Kansas City Chiefs. Wilson completed 28 of 39 passes for 245 yards and two touchdowns, rallying the Jets from a 17-0 deficit to make it a game. Wilson was making confident throws in tight windows, which has been lacking from the Jets offense in recent years. 

Place Your NFL Best Bets on the Jets vs. Broncos Week 5 Matchup NOW!

Perhaps the game will serve as a confidence boost for Wilson. We are banking on that and still don't buy the Broncos even after the 31-28 win over the Chicago Bears. Denver found itself down 28-7 before coming back, but no competent team should go behind 21 to the lowly Bears. 

⭐ My Best Bet: Jets +1.5 (-110) at FanDuel

Kansas City Chiefs vs. Minnesota Vikings Week 5 NFL Picks

The Kansas City Chiefs have garnered more attention with Taylor Swift becoming the team's latest fan through her relationship with Travis Kelce. Much of the focus has been on Swift's fandom and the eyes she's bringing to the sport, but the reality is Kansas City has bounced back from the season-opening loss to the Lions with three straight wins. 

Place Your NFL Picks on the Chiefs vs. Vikings Week 5 Matchup NOW!

Now, the Chiefs travel to face a Minnesota Vikings team that has struggled to start the season and only beat the 0-4 Carolina Panthers just last week. Minnesota has struggled defending the deep ball against competent offenses this season, which could spell trouble with Patrick Mahomes and the Chiefs. 

⭐ My Best Bet: Chiefs -4 (-110) at Caesars

Dallas Cowboys vs. San Francisco 49ers Week 5 NFL Picks & Odds

The game of the week features two of the Super Bowl favorites going up against each other. San Francisco has been downright dominant this season, going 4-0 and covering the spread in three games this season. The 49ers have won their four games by an average of 16.7 points per game. 

Place Your NFL Best Bets on the Cowboys vs. 49ers Week 5 Matchup NOW!

The San Francisco offense has been incredibly efficient. Only 29% of the 49ers drives this season have ended in a punt or turnover, which leads the league. Defensively, the team ranks third in points allowed per game at 14.5. 

Considering how the 49ers have controlled both sides of the ball so far this season, we're inclined to take them to cover the spread against the Cowboys.

⭐ My Best Bet: 49ers -4 (-110) at bet365

Green Bay Packers vs. Las Vegas Raiders Week 5 NFL Picks & Odds

Both the Packers and Raiders have issues to address before the Week 5 Monday Night Football showdown. Green Bay was destroyed by the Lions on Thursday, going down 27-3 in the first half as its run defense was nonexistent. Las Vegas also trailed early to the Chargers, going down 24-7 at the half but rallied. The Raiders had a chance to tie the game but an Aidan O'Connell interception in the red zone sealed the victory for the Chargers. 

Place Your NFL Best Bets on the Packers vs. Raiders Week 5 Matchup NOW!

It's worth monitoring whether Jimmy Garoppolo will be back to lead the Raiders offense or whether O'Connell will get another start. Whoever the Raiders start at quarterback is enough to flip this pick, but as it stands with O'Connell the projected starter, we are leaning towards Green Bay. The Packers are coming off extended rest having played on Thursday, which should allow the team to get key guys back on the offensive line to help protect Jordan Love. 

⭐ My Best Bet: Packers -1 (-110) at BetMGM

Final Words on the NFL Week 5 Predictions & NFL Best Bets Today

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To optimize your NFL betting season, it’s critical to practice responsible gambling and manage your bankroll budget effectively. As your trusted provider of daily free picks and analysis, we’re determined to bring you valuable tips and insights. Make sure to follow us for more useful information to assist in bringing you the best betting experience possible. 

Join now and make use of FanDuel Sportsbook’s generous bonus offer to help your NFL Picks. Remember, betting responsibly provides a more enjoyable and longer betting experience.

As we look forward to the thrilling NFL Week 5 matchups for today, there's another exciting development on the horizon for sports betting enthusiasts. As of September 28, Kentucky has officially launched online sports betting, paving the way for the emergence of new sports betting apps in Kentucky. This opens up a new realm of opportunities for fans and bettors alike. Stay tuned for more updates on this front.


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Bryce Derouin

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