San Francisco 49ers Odds 2025

This Week's 49ers Betting Lines

Check out the expected NFL starting lineups for this matchup. Then, you can compare these 49ers game odds to other NFL odds across the league.

Jump to: This Week's 49ers Injury Report

49ers Win Total Projections

Each NFL team plays 17 games a season. See the latest win over/under projections for the 49ers:

49ers Odds to Make the 2024 Playoffs

Just seven teams from each conference make it to the playoffs each season. Compare the 49ers latest odds to make it to the postseason with the other 31 NFL teams:

49ers Odds to Win NFC West

The San Francisco 49ers are one of four teams that play in the NFC West. The winner of each division gets an automatic bid to the NFL playoffs.

Compare the 49ers odds to win the West compared to their three competitors:

Los Angeles Rams Odds

Seattle Seahawks Odds

Arizona Cardinals Odds

49ers Odds to Win NFC Conference

The San Francisco 49ers compete in the NFC Conference. Compare their latest odds to win the NFC title to their other 15 competitors:

49ers Odds to Win Super Bowl LIX

To compare the latest Super Bowl odds, we've examined the top Super Bowl betting sites below.

You can explore more NFL futures markets with Gambling.com.

Coming Soon: 49ers Player Props

Create your own NFL player props and see odds on Nick Bosa and other 49ers players.

Latest San Francisco 49ers Stats

Quick 49ers Stats

This Week's 49ers Injuries

We list the latest 49ers injury designations here.

Official injury reports are released about two hours before each game's kickoff. It's important to monitor the latest 49ers injuries in the week (and the hours) leading up to the game before making any bet on the team.