Monday Night Football Pick: Can Cardinals Get Offense Going vs. 49ers' Defense?

Monday Night Football Pick: Can Cardinals Get Offense Going vs. 49ers' Defense?
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Here are our NFL betting picks for Monday Night Football. We'll start with our prop bets, then pick the game.

Prop Bet Picks for Today's Games

Sportsbook Odds Prop Bet
PointsBet -105 49ers’ Jimmy Garoppolo Over 245.5 passing yards
PointsBet -120 49ers’ Christian McCaffrey Over 60.5 rushing yards
PointsBet -115 Cardinals’ James Connor Under 75.5 rushing and receiving yards
Caesars -114 49ers’ Robbie Gould Over 7.5 points
FanDuel +1100 49ers’ Brandon Aiyuk to score 2+ touchdowns

For the season, player prop bets are 59-44 for 57% winning bets, averaging a +178 wager, making $958 per $50 bet.

San Francisco 49ers at Arizona Cardinals

Today, 8:15 p.m. ET, ESPN

Line: 49ers -9 | Total: 43 points

I am betting on the 49ers -9 points for 50% of my normal bet size and then 50% using the first half line -6 points as offered at BetMGM.

The 49ers sit in the seventh and final playoff spot and a win tonight moves them ½ game ahead of the Washington Commanders, who are 6-5 and in fourth place in the NFC East Division.

The 49ers have an edge on both sides of the ball against the Cardinals. The 49ers rank best in the NFL allowing an average of 281 yards per game and second-best allowing 4.7 yards per play. 

The Cardinals' offense has struggled mightily this season and ranks 29th, gaining an average of 4.9 yards per play and they rank 28th converting 35% of their third-down situations. 

The 49ers' defense, now at full strength, will present a gauntlet of troubles for the Cardinals to be capable of sustaining scoring drives tonight.

Say what you want about 49ers quarterback Jimmy Garoppolo, but he is an NFL-best 10-2 when throwing no touchdowns. 

Situational Trends and Angles

  • After Week 8, Monday Night road favorites taking on a divisional foe are 35-15 straight up (SU) and 30-20 against the spread (ATS) good for 60% winning bets since 1989. Edge: 49ers
  • As a road favorite between 6.5 and 9.5 points has produced a 15-2 SU (88%) mark and 12-5 ATS record (71%) since 1989.
  • The Cardinals are 2-8 SU (20%) and 1-9 ATS (10%) when facing a winning record team in the second half of each of the past three seasons.
  • The Cardinals are 5-9 SU (36%) and 4-10 ATS (29%) when facing a solid offensive team completing 60% or more of their pass attempts in the second half of each of the past three seasons.
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