49ers vs. Steelers NFL Odds, NFL Picks & Week 1 Predictions for 09/10

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49ers vs. Steelers Predictions & Best Bets Today: September 10, 2023

The San Francisco 49ers and Pittsburgh Steelers open the 2023-24 NFL regular season against each other for one of the marquee games of the opening weekend. Check out what bets we are looking to make for one of the top games of the Week 1 NFL schedule.

Make sure to keep reading to see who we're backing for the Week 1 games. We're also sharing our NFL best bets for the 2023-24 NFL season all year long, giving you insights into the thrilling outcomes to anticipate. Check out what bets we are looking to make for NFL Week 1 Predictions right here.

You also have the opportunity to sign up with some of the best online betting sites in the U.S., including FanDuel Sportsbook and BetMGM Sportsbook, where you can claim generous offers in bonus bets to use on the NFL Week 1.

Check out these offers to give you the best betting experience possible. Keep reading to discover more about the upcoming matchups and seize the opportunity to sign up and claim the most rewarding bonuses available.

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San Francisco 49ers vs. Pittsburgh Steelers NFL Predictions, Odds, Betting Tips

Date: Sunday, September 10, 1:00 p.m. EDT
Location: Acrisure Stadium, Pittsburgh, Pennsylvania
TV: FOX
My best bet: ⭐49ers -2.5 (-110) at BetMGM

Betting Market	San Francisco 49ers	Pittsburgh Steelers
ATS	-2.5 (-110)	+2.5 (-110)
Totals	Over 40.5 (-110)	Under 40.5 (-110)
Moneyline	(-140)	(+120)

San Francisco 49ers quarterback Brock Purdy is set to start the season after coming off UCL surgery. It's the first time since 2020 that the 49ers enter a season without a quarterback controversy. As it stands, the 49ers have another roster that can contend for a super Bowl title.

The only game Purdy lost as a starter was in the NFC Championship to the Philadelphia Eagles when he was knocked out early with an arm injury. Otherwise, we haven't seen the 49ers lose with Purdy. With the 49ers currently at -2.5 favorites, we like that number considering it's under the key football number of three.

Look for Purdy and the 49ers to continue their winning ways.

Best Betting Pick: 49ers -2.5 (-110) at BetMGM

Established 2009

⭐ Christian McCaffery Anytime TD Scorer (+100) at FanDuel

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San Franacisco 49ers vs. Pittsburgh Steelers NFL Predictions, Odds, Betting Tips

In mid-October, the San Francisco 49ers upgraded their roster by trading for and acquiring running back Christian McCaffery. Even while learning the 49ers offense on the fly, In 11 regular-season games with the 49ers, McCaffery scored 10 touchdowns as he was an early focal point of the team's offense.

For the Week 1 matchup against the Steelers, we are going to look at targeting a McCaffery prop. We like Christian McCaffery Anytime TD Scorer (+100) at FanDuel. When you add the three playoff games, McCaffery scored a touchdown in 11 of 14 games as a 49er, including a touchdown in the last nine games of the season for the team.

McCaffery is still one of the most dynamic backs in the league. He is a threat wherever he lines up, whether that is taking handoffs or catching passes out of the backfield or out of the slot. His versatility makes him a strong candidate to score a touchdown.

Best Betting Pick: Christian McCaffery Anytime TD Scorer (+100) at FanDuel

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Established 2009