Las Vegas Raiders vs. Buffalo Bills Odds, Picks & NFL Predictions for 09/17

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Las Vegas Raiders vs. Buffalo Bills Odds, Picks & NFL Predictions for 09/17
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NFL Week 2 Predictions & Raiders vs. Bills NFL Picks:


Week 2 of the NFL season brings an intriguing AFC clash as the Buffalo Bills host the Las Vegas Raiders at Highmark Stadium. 

The Bills, despite a surprising Week 1 overtime loss to the Jets, are the favorites with -400 moneyline odds and a -9.5 spread (-110) on BetMGM

On the other side, the Raiders are riding high after a narrow 17-16 win against the Broncos and are listed as +9.5 point underdogs. 

With kickoff set for 1 p.m. ET on CBS, this game is shaping up to be a must-watch. For those looking to place wagers, the best online betting sites offer a variety of NFL picks and NFL Week 1 predictions to guide your betting strategy. 

Don't miss out on this Raiders vs. Bills prediction to make the most informed bets.

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Raiders vs. Bills Betting Trends & NFL Week 2 Predictions



The NFL Week 2 odds are leaning towards the Bills, with a spread of -9.5 and a moneyline of -435. The over/under is yet to be confirmed, but given both teams' recent performances, it could be a game with a moderate scoreline, making it one of the NFL's best bets for those looking at the under.

How to Watch Raiders vs. Bills

  • Date: Sunday, Sept. 17, 2023
  • Kickoff: 1 p.m. ET
  • Location: Highmark Stadium — Orchard Park, NY
  • Where to Watch: CBS

Riding high on a surprising Week 1 victory over the Denver Broncos, the Raiders carry positive momentum into their upcoming matchup against the Buffalo Bills. Last season, the Raiders had a middling 8-8 record, but they kicked off this season with a narrow 17-16 win over the Broncos. In that game, Jimmy Garoppolo threw for 200 yards, completing 20 of 26 passes with 2 touchdowns and an interception. 

Josh Jacobs led the rushing attack with 48 yards, while Jakobi Meyers was the star receiver, pulling in 9 catches for 81 yards and 2 touchdowns. Davante Adams also contributed with 6 catches for 66 yards. Defensively, Nate Hobbs led the team with 12 tackles, and both Maxx Crosby and Jerry Tillery recorded a sack. As for the Raiders vs. Bills Odds, this newfound momentum could be a game-changer.

Raiders Injury Report: Chandler Jones - LB - (personal), Trevon Moehrig - S - (thumb), Jakobi Meyers - WR - (concussion), Brandon Facyson - CB - Out indefinitely (shin)

Check Out the Las Vegas Raiders Season Preview HERE!

After a disheartening Week 1 loss to the New York Jets, a game they were widely expected to win, the Buffalo Bills are still favored in their upcoming matchup. This favoritism stems from their solid 11-6 record last season. In their NFL season opener, Josh Allen had a lackluster performance, completing 29 of 41 passes for 236 yards, a touchdown, and three interceptions, while also adding 36 rushing yards. 

James Cook led the team in rushing with 46 yards, and Stefon Diggs was the standout receiver, hauling in 10 catches for 102 yards and a touchdown. Defensively, Terrel Bernard racked up 11 tackles, Leonard Floyd contributed 1.5 sacks, and Matt Milano snagged an interception. As NFL Picks go, the Bills remain a team to watch despite their rocky start.

Bills Injury Report: Damar Hamlin (Inactive), Von Miller (PUP list, out until Week 5)

Raiders vs. Bills Odds, NFL Picks & NFL Best Bets

Let's explore some interesting NFL betting trends and look at the Raiders vs. Bills NFL Picks and best  bets:

Raiders vs. Bills Betting Trends:

  • Raiders: Have been underdogs in 26 of their last 30 games but have a 16-9 ATS record when tagged as such.
  • Bills: Have been favorites in 20 of their last 22 games but have an 8-10-1 ATS record in those matchups.
  • Bills are 1-5 ATS in their last six games against AFC opponents
  • The UNDER is 6-1 in the Raiders' last seven road games
  • Bills: Games went under eight times last year when O/U was set at 50+.


⭐ NFL Pick 1: Raiders +9.5 ATS (-110) at BetMGM

Coming off a 1-0 start to the season, the Raiders have a recent history of thriving as underdogs, winning their last four games in such scenarios following an away victory. On the flip side, the Bills are entering this matchup with a 0-1 record and are the 9.5-point favorites. However, recent betting trends indicate that the Raiders have a 54% likelihood of covering this spread. When it comes to long-haul travel, Western teams like the Raiders have shown resilience, posting a 6-5-1 ATS record last season and an even more impressive 15-6 ATS the year prior when crossing three time zones. 

Additionally, the Raiders have a strong track record against the Bills, going 10-4 ATS in their last 14 encounters. Their second-quarter performances have also been noteworthy, covering the 2Q spread in 12 out of their last 17 games. Considering the Bills' current form and the Raiders' upward trajectory, betting on the Raiders to cover the +9.5 spread at BetMGM appears to be a well-informed wager.

⭐ NFL Pick 2: Under 47.0 total points (-110) at Caesars

With an Over/Under set at 47 points for the upcoming Raiders vs. Bills game, both teams have shown inconsistent trends in this betting category. The Bills are 0-1 for the Over this season, while the Raiders have a 1-0 record for the Under. Digging deeper, 10 of the Bills' 16 games last season went Under the total. Additionally, the Raiders have a 0-3 Over/Under record in their last three road games. Given the Bills' defensive prowess and the Raiders' pattern of hitting the 3Q Game Total Under in 7 of their last 9 away games, betting the Under 47.0 at Caesars seems like a value pick.

⭐ NFL Player Prop: Josh Allen Over 259.5 Passing Yards (-114) at FanDuel

Despite boasting impressive stats last season, Josh Allen had a dismal Week 1, throwing three interceptions and losing a fumble in a 22-16 overtime defeat to the Jets. His performance was far from his 2022 average of 267.7 passing yards per game. 

However, he faces a Raiders defense in Week 2 that ranked 30th in sacks last year and allowed successful plays on 50.7% of pass attempts. Given the Raiders' lackluster pass rush and porous secondary, Allen is poised for a bounce-back performance. Betting the Over on Allen's 259.5 passing yards at FanDuel appears to be a savvy move.

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As we look forward to the 2023 NFL regular season, there's another exciting development on the horizon for sports betting enthusiasts. Come this September, Kentucky will be launching online sports betting, paving the way for the emergence of new sports betting apps in Kentucky. This opens up a new realm of opportunities for fans and bettors alike. Stay tuned for more updates on this front.


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