NFL Week 10 Picks, Odds & NFL Predictions for All Week 10 Games

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NFL Picks & NFL Best Bets for Week 10

Week 10 of the 2023 NFL season kicks off with the Panthers vs. Bears showdown on Thursday Night Football. Sunday brings a dozen exciting matchups, while the Bills host the Broncos for Monday Night Football, so let’s take a look at the best NFL picks and predictions for all 14 games.

Before you get in on the action, check out the best online betting sites in the U.S. to get the latest NFL odds update. You can also claim the freshest bonuses and free NFL bets to get ready for Week 10.

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Carolina Panthers vs. Chicago Bears NFL Picks & Odds

Date: Thursday, November 9, 2023, 8:15 PM ET
Lines: Chicago -4.0, 39.0 O/U
TV: Amazon Prime
My Best Bet: Over 39.0 Points (-110) at BetMGM

Chicago (2-7; 3-5-1 ATS) owns Carolina’s first-rounder in 2024, so the Panthers (1-7; 1-6-1 ATS) must be highly motivated to get this one over the Bears. We’ll see a couple of bad teams in action. Carolina and Chicago both have struggled to defend all season, so I would stay away from the side bet and start Week 10 NFL predictions with Over 39.0 Points (-110) at BetMGM .

The Panthers followed their first win of the season with a 27-13 home loss to the Indianapolis Colts in Week 9. Three of their last four contests have seen more than 39 points on the scoreboard, and the Panthers are now tied with the Denver Broncos for the most points allowed in the NFL (28.3 per game). On the other side, the Bears are yielding 26.9 points per contest (tied-28^th), and each but one of their nine games in 2023 has produced more than 39 points in total.

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Both teams have injury worries ahead of Week 10. The Bears, who have dropped two straight games with Tyson Bagent under center, hope to get Justin Fields back. The Panthers might miss multiple starters on the defensive end including Xavier Woods and CJ Henderson which should help the bettors who take the over for their Panthers vs. Bears pick.

⭐ Best Betting Pick: Panthers vs. Bears Over 39.0 Points (-110) at BetMGM

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Indianapolis Colts vs. New England Patriots NFL Picks & Odds

Date: Sunday, November 12, 2023, 9:30 AM ET
Lines: Indianapolis -1.5, 43.5 O/U
TV: NFL Network
My Best Bet: Indianapolis Colts -1.5 (-110) at Caesars

Sunday’s NFL betting action starts with the Colts vs. Patriots showdown at Frankfurt Stadium in Frankfurt, Germany. The 4-5 Colts are still alive in the playoff race, whereas the 2-7 Pats are arguably out of contention, so we continue the NFL predictions with the Colts -1.5 (-110) at Caesars Sportsbook.

Indianapolis just snapped its three-game skid with a 27-13 win at Carolina in Week 10. The Colts’ defense finally showed up after yielding 37 or more points in three straight outings. We are looking for another solid performance when the Colts take on the Patriots, who own the second-lowest scoring offense in the league (15.0 points per game).

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The injury-depleted Colts defense picked off Bryce Young three times last Sunday. Mac Jones has thrown an interception in each but one of his last six starts, so keep this in mind when you’re betting the NFL player props in Week 10.

⭐ My Best Bet: Indianapolis Colts -1.5 (-110) at Caesars

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Houston Texans vs. Cincinnati Bengals NFL Picks & Odds

Date: Sunday, November 12, 2023, 1:00 PM ET
Lines: Cincinnati -7.0, 48.0 O/U
TV: CBS
My Best Bet: Houston Texans +7.0 (-110) at BetMGM

The Bengals (5-3; 4-3-1 ATS) are rolling on a four-game winning streak following a huge 24-18 home victory over the Buffalo Bills in Week 10. Joe Burrow has tossed for ten touchdowns during that stretch, and Ja’Marr Chase has caught four of those ten TD passes. Chase hurt his back last weekend and is questionable to play against the Texans (4-4; 4-4 ATS), who are 24^th in the league in passing yards allowed (234.3).

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Houston is coming off a 39-37 home win over the Tampa Bay Buccaneers in Week 10. CJ Stroud went bonkers, throwing for 470 yards and five touchdowns. Stroud, who’s enjoying a wonderful rookie season, will look to exploit the Bengals’ pass D that surrenders 234.3 yards per game (22^nd) and 12.1 yards per pass competition (31^st).

The question is whether the Texans can put enough pressure on Joe Burrow. They are eighth in the league in QB hurries per dropback (9.7%), but the Texans have only logged 17 sacks so far this season (tied-26^th). At least, Houston’s run D and offense both breed confidence, so we’re taking the Texans +7.0 (-110) at BetMGM for our next NFL pick.

⭐ My Best Bet: Houston Texans +7.0 (-110) at BetMGM

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New Orleans Pelicans vs. Minnesota Vikings NFL Picks & Odds

Date: Sunday, November 12, 2023, 1:00 PM ET
Lines: New Orleans -2.5, 40.5 O/U
TV: FOX
My Best Bet: New Orleans Saints -2.5 (-115) at FanDuel

I like the Saints (5-4; 261 ATS) in this spot. Their offense has gotten things going lately, scoring at least 24 points in three straight outings, and the Saints’ defense has been solid all season. The Saints have won two straight contests at Indianapolis 38-27 and to Chicago 24-17, and the bookies expect them to put an end to the Vikings’ four-game winning streak.

The Vikings (5-4; 5-3-1 ATS) are coming off a 31-28 road win over the Atlanta Falcons. Jaren Hall suffered a concussion, and Joshua Dobbs, who arrived at the trade deadline, threw for 158 yards and two touchdowns in relief while carrying the pigskin seven times for 66 yards and a TD. But the Falcons played the first game without their defensive anchor Grady Jarrett, and Dobbs will have a much taller task this time around. Hereof, the Saints -2.5 (-110) at FanDuel is the next NFL pick for the upcoming Sunday.

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New Orleans is yielding just 19.0 points per game (7^th) and ranks second in the NFL in opposing QB rating (72.2). The Saints have accounted for 400-plus yards on offense in three of their last four showings, and Derek Carr has tossed for 1,175 yards, six touchdowns, and two interceptions during that stretch.

⭐ My Best Bet: New Orleans Saints -2.5 (-115) at FanDuel

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Green Bay Packers vs. Pittsburgh Steelers NFL Picks & Odds

Date: Sunday, November 12, 2023, 1:00 PM ET
Lines: Pittsburgh -3.5, 39.0 O/U
TV: CBS
My Best Bet: Under 39.0 Points (-110) at BetMGM

My NFL predictions for Week 10 say we are going to see a low-scoring affair at Acrisure Stadium in Pittsburgh. The Steelers (5-3; 5-3 ATS) have won three of their last four contests, and only one of their previous five games has seen more than 36 points on the scoreboard. On the other side, the Packers (3-5; 4-4 ATS) stopped a four-game slide with a 20-3 home win over the LA Rams in Week 9 which was Green Bay’s fourth straight outing with fewer than 37 points in total.

The Steelers rank 25^th in the league in yards allowed per play (5.5), but they are second in opposing turnover percentage (17.6%). The Packers allow just 4.9 yards per play (tied-5^th) and 19.9 points per game (10^th). A couple of inexperienced quarterbacks will be under huge pressure this coming Sunday, and we’re taking the Under 39.0 Points (-110) at BetMGM for our best NFL pick in the Packers vs. Steelers showdown.

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The betting trends are pretty much backing our NFL prediction for this matchup. The under is 5-1 in Green Bay’s last six games overall and 6-0 in Pittsburgh’s previous six. Also, four of the Steelers’ last five home contests have gone under the total.

⭐ My Best Bet: Under 39.0 Points (-110) at BetMGM

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Tennessee Titans vs. Tampa Bay Buccaneers NFL Picks & Odds

Date: Sunday, November 12, 2023, 1:00 PM ET
Lines: Tampa Bay -1.0, 38.5 O/U
TV: CBS
My Best Bet: Will Levis Over 213.5 Passing Yards (-110) at DraftKings

The next stop on our Week 10 NFL predictions is the interconference battle between Tennessee and Tampa Bay. This is arguably one of the toughest matchups to bet on this weekend, as both teams have struggled to perform at a high level over the last few weeks. The Titans (3-5; 4-4 ATS) have only won one of their previous four contests, while the Buccaneers (3-5; 5-3 ATS) are on a four-game losing streak.

There are a few interesting NFL player props in this matchup. We are going to target Will Levis Over 213.5 Passing Yards (-110) at DraftKings, and DeAndre Hopkins Anytime TD Scorer (+167) is another intriguing pick. The Buccaneers have allowed 13 touchdowns through the air so far this season while surrendering a staggering 279.4 passing yards per game.

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In each of their last four showings, the Bucs have yielded way more than 213 passing yards. Will Levis will make his third start in the NFL, and rookie signal-caller has thrown for 500 yards, four touchdowns, and an interception over his previous two outings.

⭐ My Best Bet: Will Levis Over 213.5 Passing Yards (-110) at DraftKings

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San Francisco 49ers vs. Jacksonville Jaguars NFL Picks & Odds

Date: Sunday, November 12, 2023, 1:00 PM ET
Lines: San Francisco -3.0, 45.0 O/U
TV: FOX
My Best Bet: Under 45.0 Points (-110) at bet365

We’re heading into another interconference clash on our NFL prediction card, and this one will be a joy to watch. The 49ers (5-3; 4-4 ATS) are on a three-game losing streak and desperate to get back on the right track. On the other side, the Jaguars (6-2; 6-2 ATS) are rolling on a five-game winning streak and want to prove their worth in a matchup against one of the best teams in the league.

The Niners, who are coming off a bye, have struggled with injuries during their losing streak. Deebo Samuel will return to the field after missing two straight games due to a shoulder injury, but Trent Williams remains questionable after missing Wednesday’s practice. Williams is a key player in San Francisco’s offensive line, and his eventual absence would help the Jags’ defense continue to shine.

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Jacksonville allows 19.5 points per game (tied-8^th), while San Francisco surrenders 17.5 points per contest (4^th). Both teams are doing a great job against rushing and are capable of putting pressure on the opposing quarterbacks. That’s why we’re picking the Under 45.0 Points (-110) at bet365 for our best 49ers vs. Jaguars pick.

⭐ My Best Bet: Under 45.0 Points (-110) at bet365

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Cleveland Browns vs. Baltimore Ravens NFL Picks & Odds

Date: Sunday, November 12, 2023, 1:00 PM ET
Lines: Baltimore -6.0, 38.0 O/U
TV: FOX
My Best Bet:Under 38.0 Points (-110) at Caesars

Now, our NFL predictions switch focus to a highly-anticipated AFC North showdown at M&T Bank Stadium in Baltimore. The Browns (5-3; 4-3-1 ATS) face off against the Ravens (7-2; 6-3 ATS) for the second time this term, and Baltimore routed Cleveland 28-3 as a 1.5-point road fave with a total of 38.5 points in Week 4.

The Ravens have won four games in a row, surrendering just 49 points in that stretch. Over their previous two outings at home, the Ravens have destroyed Detroit 38-6 and Seattle 37-3. On the other side, the Browns have gone 3-1 SU in their last four games overall. They blanked Arizona 27-0 last Sunday.

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The total has gone under in four of the last five encounters between Cleveland and Baltimore. We’ll follow this betting trend and take the Under 38.0 Points (-110) at Caesars for our best Browns vs. Ravens pick. The Ravens lead the NFL in points allowed (13.8), while the Browns, who should have enough firepower to slow down Baltimore’s ground game, are third in the league with 17.4 points allowed per game.

⭐ My Best Bet: Under 38.0 Points (-110) at Caesars

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Atlanta Falcons vs. Arizona Cardinals NFL Picks & Odds

Date: Sunday, November 12, 2023, 4:05 PM ET
Lines: Atlanta -1.5, 44.0 O/U
TV: CBS
My Best Bet: Atlanta Falcons -1.5 (-110) at FanDuel

The Falcons (4-5; 2-7 ATS) are desperate for a win to snap their two-skid and keep pace with the Saints in the race for the NFC South title. On the other side, the lowly Cardinals (1-8; 4-5 ATS) are on a six-game losing streak following a 27-0 defeat at Cleveland in Week 9. They’ll get Kyler Murray back, but we are still adding the Falcons -1.5 (-110) at FanDuel to Week 10 NFL picks.

Arizona’s ground game has struggled since James Conner landed on the IR in Week 6. The Cardinals have surrendered 26 or more points in each but one of their previous six showings, and their run D is giving up 128.7 yards per game (26^th).

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The Falcons, who average 124.4 rushing yards per contest (9^th), should roll over Arizona. Their defensive unit misses Grady Jarrett, but we are expecting Atlanta’s offense to make a difference in this matchup.

We're going to go with the Commanders getting +3.5 to cover.

⭐ My Best Bet: Atlanta Falcons -1.5 (-110) at FanDuel

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Detroit Lions vs. Los Angeles Chargers NFL Picks & Odds

Date: Sunday, November 12, 2023, 4:05 PM ET
Lines: Detroit -3.0, 48.5 O/U
TV: CBS
My Best Bet: Los Angeles Chargers +3.0 (-110) at BetMGM

If you like to tease your NFL picks, take the Chargers (4-4; 4-4 ATS) when they host the Lions (6-2; 6-2 ATS) as 3-point underdogs. As I’ve mentioned many times, this Chargers team is built to play close games. And with Justin Herbert under center, the Chargers can comfortably play from behind against any team in the league.

Los Angeles’ defense has improved over the last couple of weeks, as the Chargers beat Chicago 30-13 in Week 8 and the NY Jets 27-6 in Week 9. It’s fair to say that the Lions are a much better offensive team than both the Bears and Jets, but we still doubt their chances to easily beat the Chargers on the road.

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David Montgomery is on track to return from a two-game absence caused by a rib cartilage, and the Lions are coming off a bye as healthy as they’ve been all season. They will probably continue to lean on Jared Goff’s arm because the Chargers surrender just 3.7 yards per carry, so keep your eyes on Detroit’s signal-caller if you like betting the NFL player props. Goff has thrown for 272 or more yards in three straight outings.

⭐ My Best Bet: Los Angeles Chargers +3.0 (-110) at BetMGM

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New York Giants vs. Dallas Cowboys NFL Picks & Odds

Date: Sunday, November 12, 2023, 4:25 PM ET
Lines: Dallas -16.5, 38.5 O/U
TV: FOX
My Best Bet: Dallas Cowboys -16.5 (-110) at Caesars

Laying 16.5 points in a divisional matchup is rarely a smart move. But the Cowboys (5-3; 5-3 ATS) love to smash bad teams, and the Giants (2-7; 2-6-1 ATS) are a bad, injury-depleted team at the moment.

Daniel Jones and Tyrod Taylor are both out, so rookie Tommy DeVito should start under center in Week 10. Last Sunday, the Giants were trounced by the Raiders 30-6, and DeVito went 15-of-20 for 175 yards, a touchdown, and two interceptions.

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The Cowboys humiliated the Giants 40-0 in Week 1. Dallas is 5-0 SU and 4-1 ATS in its last five dates with the Giants, so we are going with the Cowboys -16.5 (-110) at Ceasars for our next NFL pick. The Cowboys will be highly motivated to bounce back from last week’s 28-23 defeat at the Philadelphia Eagles, and they could easily dismantle New York once more.

⭐ My Best Bet: Dallas Cowboys -16.5 (-110) at Caesars

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Washington Commanders vs. Seattle Seahawks NFL Picks & Odds

Date: Sunday, November 12, 2023, 4:25 PM ET
Lines: Seattle -6.0, 45.5 O/U
TV: FOX
My Best Bet: Over 45.5 Points (-110) at FanDuel

The Seahawks (5-3; 4-3-1 ATS) must be fired up to bounce back from an embarrassing 37-3 defeat at Baltimore in Week 9. They are strong favorites to beat the Commanders (4-5; 4-4-1 ATS), but we are looking at the total for our best NFL prediction.

Washington just stopped a two-game slide with a 20-17 road victory over New England. However, the Commanders put zero pressure on Mac Jones, and their defense has struggled a lot for most of the season. Washington is yielding 27.2 points per game (30^th in the NFL) on 252.7 passing yards (27^th) and 116.2 rushing yards (20^th), while Seattle is giving up 21.9 points per contest (22^nd) on 232.1 passing yards (20^th) and 122.0 rushing yards (21^st).

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After a tough road matchup against Baltimore’s stifling defense, the Seahawks’ offense will get things going in this game, but their defense shouldn’t be able to shut down Washington. Give us Over 45.5 Points (-110) at FanDuel for the best Commanders vs. Seahawks pick.

⭐ My Best Bet: Over 45.5 Points (-110) at FanDuel

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New York Jets vs. Las Vegas Raiders NFL Picks & Odds

Date: Sunday, November 12, 2023, 8:20 PM ET
Lines: New York -1.0, 36.0 O/U
TV: NBC
My Best Bet: Las Vegas Raiders +1.0 (-110) at BetMGM

Week 10 Sunday Night Football will see the Jets vs. Raiders showdown at Allegiant Stadium in Las Vegas. Both teams have gone 3-2 SU over their last five outings and are alive in the playoff race. It’s a huge game for either side and could easily go either way.

The Jets (4-4; 4-3-1 ATS) are coming off a 27-6 home loss to the Chargers that put an end to their three-game win streak. Zach Wilson completed 33 of his 49 passing attempts for a season-high 263 yards, but he also lost a couple of fumbles.

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On the other side, the Raiders (4-5; 4-5 ATS) hammered the NY Giants 30-6 last Sunday. Las Vegas interim head coach Antonio Pierce emerged victorious on his debut, while Josh Jacobs rushed 26 times for 98 yards and two touchdowns. We are looking for another strong performance from Jacobs, as New York allows 137.3 rushing yards per game. His rushing yards prop is unavailable at the moment, so we are taking Las Vegas +1.0 (-110) at BetMGM for the Sunday Night Football pick.

⭐ My Best Bet: Las Vegas Raiders +1.0 (-110) at BetMGM

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Denver Broncos vs. Buffalo Bills NFL Picks & Odds

Date: Monday, November 13, 2023, 8:15 PM ET
Lines: Buffalo -7.5, 47.0 O/U
TV: ABC/ESPN
My Best Bet: Denver Broncos +7.5 (-110) at bet365

We’ll round up our NFL Week 10 predictions with Monday Night Football from Highmark Stadium in Orchard Park, New York. The Broncos (3-5; 2-5-1 ATS) are coming off a bye and ready to rumble, searching for their third straight victory, whereas the Bills (5-4; 3-6 ATS) want to bounce back from a 24-18 defeat at the Cincinnati Bengals in Week 9.

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Denver has improved a lot since Week 3 and a humiliating 70-20 loss at Miami. The Broncos have allowed 19 or fewer points in three straight showings. Back in Week 8, they stunned the Kansas City Chiefs 24-9 as 6.5-point home underdogs, winning the turnover battle 5-1.

The Broncos picked off Patrick Mahomes twice. Now, they take on Josh Allen, who’s thrown an interception in five straight weeks. The Bills desperately need a win after dropping three of their last five contests. They are arguably a better team than Denver, but we are backing the Broncos to keep it close on Monday night. The Bills haven’t beaten the number in five consecutive outings.

⭐ My Best Bet: Denver Broncos +7.5 (-110) at bet365

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