NFL Week 2 Predictions, Odds, NFL Picks & Preview for All 16 NFL Games

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NFL Picks & NFL Best Bets for Week 2

The NFL is regularly one of the most bet on sports in the United States, and with the first week of the the NFL regular season completed, sportsbooks have already posted betting lines and NFL Picks for Week 2 for bettors to wager on.

To get you ready for the NFL betting season, we’re providing you with some of our NFL best bets and picks. We’re also providing showing you the new sportsbook promotions, best bets and bonuses offered by two of the best online betting sites: FanDuel Sportsbook and bet365. Take advantage of these bonus bets and generous bonuses to help you solidify your NFL betting bankroll.

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Read our detailed analysis and NFL betting picks, giving you the information necessary to make valuable bets and have a fun viewing experience. Become informed, hone your betting skills and get ready to prepare to place the NFL picks that will give you a chance to earn more winners.

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Minnesota Vikings at Philadelphia Eagles NFL Picks & Odds

Date: Thursday, Sept. 14, 2023, 8:15 p.m.
TV: Prime Video
My Best Bet: Eagles -7 (-110) at bet365 Sportsbook

The Philadelphia Eagles deserve credit for going on the road and defeating the New England Patriots 25-25 on the road. Jalen Hurts was solid, completing 22 of 33 passes for 170 yards and a touchdown, while the defense recorded three sacks and held the Patriots to just 3.5 yards per attempt on the ground.

⭐ Place Your NFL Picks on the Vikings vs. Eagles Week 2 Matchup NOW! ⭐

Now, Philadelphia will host the Minnesota Vikings who struggled in the 20-17 loss to the Tampa Bay Buccaneers. Minnesota turned the ball over three times and could not sustain anything on the ground, gaining just 41 yards on 17 carries (2.4). On a short week on the road at the defending NFC champions, turnover issues and the inability to run the ball will cost them. We like the Eagles to cover.

My Best Bet: Eagles -7 (-110) at bet365 Sportsbook

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Green Bay Packers at Atlanta Falcons NFL Week 2 Predictions

Date: Sunday, Sept. 17, 2023, 1:00 p.m. EDT
TV: FOX
My Best Bet: Packers -2 (-110) at BetMGM

We're buying into the Jordan Love hype after the 38-20 win over the Chicago Bears.. The Green Bay Packers quarterback excelled in Week 1 with 245 yards passing and three touchdowns to account for a 123.2 quarterback rating. Aaron Jones was also dynamic with two touchdowns, including a 51-yard reception and had 127 yards of total offense.

⭐ Place Your NFL Picks on the Packers vs. Falcons Week 2 Matchup NOW! ⭐

This line has moved from -1 to -2 in Green Bay's favor, but much of this game could be dependent on the health of Jones, who was nursing a hamstring injury after the win over Chicago and wide receiver Christian Watson who is also dealing with a hamstring issue. Green Bay's defense was also dominant at times against Chicago, forcing two turnovers and recording four sacks. This should be a step up in competition for an Atlanta team that went up against a rookie quarterback in Bryce Young and new Carolina coach Frank Reich.

My Best Bet: Packers -2 (-110) at BetMGM

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Las Vegas Raiders vs. Buffalo Bills NFL Week 2 Predictions

Date: Sunday, Sept. 10, 2023, 1 p.m. EDT
TV: CBS
My Best Bet: Bills -9.5 (-110) FanDuel

Despite the strange loss to the New York Jets on Monday night, the Buffalo Bills have the luxury of returning home on Sunday to face the Las Vegas Raiders in the early Sunday spot. Traditionally, West Coast teams who play at 1 p.m. are at a disadvantage as their bodies get acclimated to playing at an earlier scheduled time.

⭐ Place Your NFL Picks on the Raiders vs. Bills Week 2 Matchup NOW! ⭐

The Raiders earned a 17-16 win against Denver, but the Raiders defense still allowed 4.5 yards per play to the lowly Broncos and Las Vegas only gained 261 yards of offense themselves. Expect Josh Allen to take care of the ball better and for a focused Buffalo squad to bounce back.

My Best Bet: Bills -9.5 (-110) FanDuel

Established 2009

⭐ Place Your NFL Best Bets on the Ravens vs. Bengals Week 2 Matchup NOW! ⭐

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Baltimore Ravens vs. Cincinnati Bengals NFL Picks & Odds

Date: Sunday, Sept. 17, 2023, 1:00 p.m. EDT
TV: CBS
My Best Bet: Ravens +3.5 (-110) at Caesars

The Baltimore Ravens were solid in the 25-9 win over the Houston Texans, even with an average return from Lamar Jackson who threw for just 169 yards and an interceptiona nd added only 38 yards rushing o the ground. It was Baltimore's defense that led the way by limiting the Texans to just 3.7 yards per play.

Cincinnati didn't inspire any confidence on offense during the 24-3 loss to the Cleveland Browns. It's fair to wonder if the extended time Joe Burrow missed due to a calf injury played any role in the Bengals offense looking dysfunctional early on. Burrow completed just 14 of 31 passes for 82 yards. There are too many concerns to want to back Cincinnati right now.

My Best Bet: Ravens +3.5 (-110) at Caesars

Established 2013

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Kansas City Chiefs vs. Jacksonville Jaguars Week 2 NFL Picks

Date: Sunday, Sept. 17, 2023, 1:00 p.m. EDT
TV: CBS
My Best Bet: Chiefs -3 (-110) FanDuel

This should be a bounce-back spot for the Kansas City Chiefs, who already got good news this week with defensive lineman Chris Jones set to return after holding out. Jones and the Chiefs came to a new contract, which will bolster Kansas City's defensive front. It remains unknown if tight end Travis Kelce will be back for the Chiefs as he deals with an injury he suffered in practice that kept him out of the Detroit game.

With the Chiefs getting healthy and having three extra days to prepare, we like Kansas City to bounce back. Much of the Chiefs' miscues were self-inflicted like dropped passes or the Detroit pick-six that was off a bounce. Don't overreact to one loss and back the Chiefs.

My Best Bet: Chiefs -3 (-110) FanDuel

Established 2009

⭐ Place Your NFL Best Bets on the Titans vs. Chargers Week 2 Matchup NOW! ⭐

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Los Angeles Chargers vs. Tennessee Titans Week 2 NFL Picks

Date: Sunday, Sept. 17, 2023, 1:00 p.m. EDT
TV: CBS
My Best Bet: Chargers -3 (-110) at bet365

The offense wasn't the problem for the Los Angeles Chargers in the 36-34 loss to the Miami Dolphins. Los Angeles finished with 433 yards of offense and Justin Herbert completed 23 of 33 passes for 228 yards and a touchdown, while Austin Ekeler gained 117 yards rushing and scored a touchdown.

As for Tennessee, the Titans showed no signs of being able to keep up with a high-powered offense like the Chargers during the 16-15 loss to the New Orleans Saints. Tennessee had three turnovers and only 285 yards of offense as Ryan Tannehill looked bad, completing just 16 of 34 passes for 198 yards and three interceptions.

My Best Bet: Chargers -3 (-110) at bet365

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⭐ Place Your NFL Best Bets on the Seahawks vs. Lions Week 2 Matchup NOW! ⭐

Seattle Seahawks vs. Detroit Lions Week 2 NFL Picks

Date: Sunday, Sept. 17, 2023, 1:00 p.m. EDT
TV: FOX
My Best Bet: Lions -6 (-110) at BetMGM

Ford Field should be rocking for the Detroit Lions first home game of 2023. Detroit upset the Kansas City Chiefs on the road, 21-20, to start the NFL regular season and there was a strong contingent of Lions fans at that game. The Lions closed out the defending Super Bowl champions on the road in a gritty performance that included multiple fourth-quarter stops against Kansas City quarterback Patrick Mahomes.

The homefield advantage, plus Seattle playing on the east coast in the early slot will give the Lions an edge. Seattle looked lost in the 30-13 loss to the Los Angeles Rams and had just 180 yards of offense in the defeat. We expect Detroit to roll.

My Best Bet: Lions -6 (-110) at BetMGM

Established 2018

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Indianapolis Colts vs. Houston Teaxns Week 2 NFL Picks

Date: Sunday, Sept. 17, 2023, 1:00 p.m. EDT
TV: FOX
My Best Bet: Colts -1 (-110) FanDuel

This will provide a great look at two of the top rookie quarterbacks in Indianapolis' Anthony Richardson and C.J. Stroud of the Houston Texans. Both were just OK in their debuts, with Richardson throwing for 223 yards and a touchdown and an interception, while Stroud accumulated 242 yards. Both teams lost by double digits.

⭐ Place Your NFL Picks on the Colts vs. Texans Week 2 Matchup NOW! ⭐

We're going to give the slight edge to Indianapolis considering the Colts showed more on offense in the 31-21 loss to Jacksonville. Indianapolis has a solid connection between Richardson and Michael Pittman Jr, who had 97 yards on eight catches, while Houston still lacks any offensive playmakers around Stroud to make the offense dangerous.

My Best Bet: Colts -1 (-110) FanDuel

Established 2009

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Chicago Bears vs. Tampa Bay Buccaneers Week 2 NFL Picks

Date: Sunday, Sept. 17, 2023, 1:00 p.m. EDT
TV: FOX
My Best Bet: Buccaneers -3 (-110) at Caesars

The Chicago Bears looked every bit of the same struggling team from a year ago in the 38-20 loss to the Green Bay Packers. Chicago still couldn't block, allowing four sacks, and the offense was redundant and conservative with short passes to the sideline that weren't a threat to do anything. Defensively, they made Jordan Love look like the next great quarterback for the Packers.

Meanwhile, the Tampa Bay Buccaneers pulled off a large upset, beating the Minnesota Vikings 20-17 as six-point underdogs. Baker Mayfield threw for two touchdowns in his Tampa Bay debut and the Buccanneers' opportunistic defense forced three turnovers to secure the victory.

We like Tampa Bay here.

My Best Bet: Buccaneers -3 (-110) at Caesars

Established 2013

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⭐ Place Your NFL Best Bets on the Giants vs. Cardinals Week 2 Matchup NOW! ⭐

New York Giants vs. Arizona Cardinals Week 2 NFL Picks

Date: Sunday, Sept. 17, 2023, 4:05 p.m. EDT
TV: FOX
My Best Bet: Under 39.5 (-110) at bet365

The Arizona Cardinals are expected to be a bad team, while the New York Giants played like the worst team in the league in the 40-0 loss to the Dallas Cowboys. At least Arizona kept it close with Washington and only loss 20-15, even with career journeyman Josh Dobbs playing quarterback while not knowing the majority of names of his teammates.

Instead of picking a side, we're just going with the under and hoping both teams continue their bad starts on offense. A group of mannequins would have been better as an offensive line for New York against Dallas with the Giants allowing seven sacks and only picking up 171 yards of offense. The Cardinals weren't much better with just 210 yards, and Dobbs didn't exactly inspire any confidence after throwing for 132 yards.

I feel bad for anyone who has to watch this game.

My Best Bet: Under 39.5 (-110) at bet365

Established 2001

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San Francisco 49ers vs. Los Angeles Rams Week 2 NFL Picks

Date: Sunday, Sept. 17, 2023, 4:05 p.m. EDT
TV: FOX
My Best Bet: 49ers -8 (-110) at BetMGM

Give the Los Angeles Rams credit for exceeding expectations and beating the Seattle Seahawks 30-13 as 4.5-point underdogs. Matthew Stafford was efficient in his return, completing 24 of 38 passes for 334 yards, while Kyren Williams added two rushing touchdowns. The Rams' defense held Seattle to just 180 yards of offense.

⭐ Place Your NFL Best Bets on the 49ers vs. Rams Week 2 Matchup NOW! ⭐

But the Rams will now have to face a loaded 49ers team that looked downright dominant in the 30-7 win over the Steelers. Brock Purdy looked great in his return from arm surgery, throwing for 220 yards and two touchdowns, while Christian McCaffrey added 152 yards rushing and a 65-yard touchdown. The 49ers are still unbeaten when Purdy starts and finishes a game, and we like them to cover the large spread on the road.

My Best Bet: 49ers -8 (-110) at BetMGM

Established 2018

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⭐ Place Your NFL Best Bets on the Jets vs. Cowboys Week 2 Matchup NOW! ⭐

New York Jets vs. Dallas Cowboys Week 2 NFL Picks

Date: Sunday, Sept. 17, 2023, 4:25 p.m. EDT
TV: CBS
My Best Bet: Cowboys -8.5 (-110) at FanDuel

Both the Dallas Cowboys and New York Jets earned wins in Week 1, but they enter this week on opposite ends of the emotional spectrum. The Jets are grieving the loss of quarterback Aaron Rodgers who tore his Achilles on the fourth play of Monday night's win over the Bills. Meanwhile, the Cowboys looked every bit of a Super Bowl contender in the 40-0 win over the rival New York Giants.

With New York set to run out Zach Wilson at quarterback, we like the Cowboys to cover. Wilson was shaky against Buffalo and New York's only ability to move the ball came on the ground or on short screens. Expect Dallas to be prepared to stop all the dink-and-dunk passes and load up to the stop the run. G

My Best Bet: Cowboys -8.5 (-110) at FanDuel

Established 2009

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Washington Commanders vs. Denver Broncos Week 2 NFL Picks

Date: Sunday, Sept. 17, 2023, 4:25 p.m. EDT
TV: CBS
My Best Bet: Under 38 (-110) at Caesars

It was more of the same for the Denver Broncos, who were a notoriously bad team on offense a year ago and looked similar in a 17-16 loss to the Las Vegas Raiders. Russell Wilson managed two touchdowns but just 177 yards as Denver failed to convert long drive into better scoring opportunities. One 75-yard drive ended with a field goal, and another 10-play drive was capped by a missed field goal. In the second year with Wilson, the offensive issues remained evident as the team failed to put up points.

Washington and second-year quarterback Sam Howell struggled to beat the lowly Arizona Cardinals, winning 20-16. The Comanders had just 248 yards of offense and 3.8 yards per play. Add in Denver's offensive issues, and we like the under in what should be another low-scoring contest.

My Best Bet: Under 38 (-110) at Caesars

Established 2013

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Miami Dolphins vs. New England Patriots Week 2 NFL Picks & Odds

Date: Sunday, Sept. 17, 2023, 8:20 p.m. EDT
TV: NBC
My Best Bet: Over 46.5 (-110) at bet365

Expect another high-scoring game with the Miami Dolphins taking on the New England Patriots. The Dolphins are coming off an impressive 36-34 win over the Los Angeles Chargers where Tua Tagovailoa threw for 466 yards and three touchdowns. Miami's vaunted offense put up 536 yards of offense and averaged 8.2 yards per play.

New England's offense was solid against the Super Bowl runner-up Philadelphia Eagles, with Mac Jones throwing for 316 yards and three touchdowns, which should make this another high-scoring shootout with the Dolphins. Look for both offenses to attempt to match each other through the air, which should lead to plenty of scoring opportunities.

My Best Bet: Over 46.5 (-110) at bet365

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New Orleans Saints at Carolina Panthers Week 2 NFL Picks & Odds

Date: Monday, Sept. 18, 2023, 7:15 p.m. EDT
TV: ESPN
My Best Bet: Saints -3 (-110) at BetMGM

The Carolina Panthers bad preseason, where the team went 0-3, carried over into the regular season with the team falling 24-10 to the Atlanta Falcons to open the regular season. Carolina is a team in transition with new coach Frank Reich and rookie quarterback Bryce Young getting acclimated to the NFL. The Panthers had just 281 yards of offense, while Young struggled with just 146 yards passing and two interceptions.

We will take the New Orleans Saints to cover in this game. Veteran quarterback Derek Carr was solid in his New Orleans debut, passing for 305 yards and a touchdown to go with an interception, while the Saints defense held the Titans to only 285 yards and just 198 yards passing.

New Orleans' stingy defense and Carr's veteran experience should push them over against Tennessee.

My Best Bet: Saints -3 (-110) at BetMGM

Established 2018

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⭐ Place Your NFL Best Bets on the Browns vs. Steelers Week 2 Matchup NOW! ⭐

Cleveland Browns vs. Pittsburgh Steelers Week 2 NFL Picks

Date: Monday, Sept. 18, 2023, 8:15 p.m. EDT
TV: ABC
My Best Bet: Browns -2.5 (-110) at FanDuel

The Cleveland Browns looked downright dominant in the 24-3 Week 1 win over the Cincinnati Bengals, holding them to just 154 yards and only 2.6 yards per play. Cleveland's win highlighted the potential of its defense when its front seven are able to get pressure and throw offenses out of sync,

We like Cleveland to cover in this game considering the Pittsburgh Steelers had similar offensive issues in the Week 1 30-7 loss to the San Francisco 49ers. Pittsburgh starting quarterback Kenny Pickett was bad, converting on just 31 of 46 passes for 232 yards and two interceptions to just one touchdown. With top wide receiver Diontae Johnson also set to miss this game, we like the Browns in the spot to continue their early dominance.

My Best Bet: Browns -2.5 (-110) at FanDuel

Established 2009