NFL Week 4 Predictions, Odds & NFL Picks for All 16 Games

Date IconLast Updated: Sep 30th, 2023
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NFL Week 4 Predictions, Odds & NFL Picks for All 16 Games
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NFL Picks & NFL Best Bets for Week 4

The NFL regular season continues with Week 4 as the storylines and the Super Bowl chase continues with another week. 

To get you ready for the NFL betting season, we’re providing you with some of our NFL best bets and picks. We’re also providing showing you the new sportsbook promotions, best bets and bonuses offered by two of the best online betting sites: FanDuel Sportsbook and bet365. Take advantage of these bonus bets and generous bonuses to help you solidify your NFL betting bankroll. 

We’re here to assist you in signing up for a sportsbook to ensure you take advantage of the bonuses offered by the best online betting sites. 

Read our detailed analysis and NFL betting picks, giving you the information necessary to make valuable bets and have a fun viewing experience. Become informed, hone your betting skills and get ready to prepare to place the NFL picks that will give you a chance to earn more winners. 

⭐ Check Out the Best NFL Betting Trends for Week 4! ⭐ 

Detroit Lions at Green Bay Packers NFL Picks & Odds

The Green Bay Packers are coming off an improbably 18-17 win over the New Orleans Saints. Green Bay trailed 17-0 heading into the fourth quarter before rallying for one of the biggest comebacks of the season. Now, Green Bay will host the Detroit Lions, who are also 2-1, with the winner taking sole possession of the lead in the NFC North. 

Green Bay had some early good news this week with starting running back Aaron Jones and starting wide receiver Christian Watson both expected to play against Detroit. Jones hasn't played since injuring his hamstring during the Week 1 win over the Chicago Bears, while Watson has yet to debut this season. Cornerback Jaire Alexander also practiced on Tuesday, which bodes well for his return after missing the Saints game. 

Place Your NFL Picks on the Lions vs. Packers Week 4 Matchup NOW!

The Packers have historically been good against the Lions at home, winning 27 of their last 30 games against Detroit at Lambeau Field. With the Packers getting key guys back and in a revenge spot after losing to Detroit and missing the playoffs in the final week of the 2023 regular season, we're going with the Packers in this spot. 

My Best Bet: Packers +1.5 (-110) at bet365 Sportsbook


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Atlanta Falcons at Jacksonville Jaguars NFL Week 4 Predictions

The Jacksonville Jaguars were on the wrong end of one of the bigger upsets in Week 3, losing to the Houston Texans 37-17 as 7.5-point favorites. Now, Jacksonville will attempt to bounce back against an Atlanta Falcons group that struggled on the road in their first away game, falling 20-6 to the Detroit Lions.

Place Your NFL Picks on the Falcons vs. Jaguars Week 4 Matchup NOW!

Atlanta quarterback Desmond Ridder has yet to prove he can perform or win on the road in the NFL. Sunday's loss put his road record as an NFL starting quarterback at 0-3 and he has yet to throw a touchdown in either of those games. It was also alarming how bad the Falcons' offensive line was against Detroit, allowing seven sacks. 

Given Ridder's road struggles, we like the Jaguars to cover in this one. 

My Best Bet: Jaguars -3 (-110) at BetMGM

Miami Dolphins vs. Buffalo Bills NFL Week 4 Predictions

The Miami Dolphins made history during the 70-20 win over the Denver Broncos, setting the record for most points by an NFL team in a game since 1966. Miami gained 726 yards of offense, averaging 10.2 yards per play and finished with 376 yards passing and 350 yards rushing to tally one of the greatest offensive games in recent NFL history. 

Place Your NFL Picks on the Dolphins vs. Bills Week 4 Matchup NOW!

Buffalo has also found its offensive rhythm after the Week 1 loss to the New York Jets, putting up 38 points in a win over the Las Vegas Raiders and 37 versus the Washington Commanders in Week 3. Given the offensive firepower of both of these teams, we expect a high-scoring game and like the over in this matchup.

My Best Bet: Over 53.5 (-110) FanDuel

Denver Broncos at Chicago Bears Week 4 NFL Picks & Odds

This. might be the game no one wants to watch. Denver just gave up the most points in an NFL game since 1966 by allowing the Miami Dolphins to put up 70 against the team, while the Bears trailed 34-0 at halftime to the Kansas City Chiefs before losing 41-10. The Bears have barely been competitive at all this season, losing by 18 to the Packers, 10 to the Tampa Bay Buccaneers before the blowout loss to the Chiefs. 

Place Your NFL Best Bets on the Broncos vs. Browns Week 4 Matchup NOW!

This could come down to whatever team is the least dysfunctional. Chicago has a myriad of issues between former defensive coordinator Alan Williams resigning abruptly last week, and quarterback Justin Field questioning the coaching. We're going to take Denver, but not feel great either way with a pick in this game. 

My Best Bet:  Broncos -3.5 (-110) at Caesars


Check Out the Best NFL Player Props for Week 4!

Baltimore Ravens vs. Cleveland Browns Week 4 NFL Picks

One of the upsets that flew under the radar with the Cowboys losing to the Cardinals and Jaguars falling to the Texans was the Baltimore Ravens getting upset by second-string quarterback Gardner Minshew and the Indianapolis Colts. Now, the Ravens will attempt to bounce back against the division rival Cleveland Browns, who handled the Titans 27-3 in their first game without running back Nick Chubb.

Place Your NFL Best Bets on the Ravens vs. Browns Week 4 Matchup NOW!

We're going to go with the Ravens in this one. Lamar Jackson looked like the true mobile threat last year, running for 101 yards to go with 202 yards passing. With Jackson as one of the elite dual-threat quarterbacks, the Ravens become one of the toughest teams to defend. 

Since 2022, Baltimore also owns an 8-3 record against the spread while on the road, which is the best in the league. We like the Ravens to cover in this one, too. 

My Best Bet: Ravens +2.5 (-110) FanDuel

Pittsburgh Steelers vs. Houston Texans Week 4 NFL Picks

After a blowout loss to the San Francisco 49ers in Week 1, the Steelers have bounced back with two straight wins, thanks to its chaotic defense. Pittsburgh forced four turnovers and recorded six sacks in the 26-22 win over the Cleveland Browns before getting three interceptions and four sacks against the Las Vegas Raiders in the 23-18 victory. 

Place Your NFL Best Bets on the Steelers vs. Texans Week 4 Matchup NOW!

We're going to take Pittsburgh's recent dominant defensive run against the Houston Texans. This could be a learning moment for rookie quarterback C.J. Stroud, going against Pittsburgh's experienced pass rush. With how Pittsburgh has turned over teams recently, it could be troublesome for Stroud and an offense in a new system under first-year head coach DeMeco Ryans. 

My Best Bet: Steelers -3 (-110) at bet365

Minnesota Vikings vs. Carolina Panthers Week 4 NFL Picks

The Vikings and Panthers both share the distinction of an 0-3 record and 0-3 mark against the spread this season. one of these teams will finally get a win and a cover. We're going with the Vikings considering the questions that remain for the Carolina Panthers. Bryce Young didn't play in Sunday's loss to the Seahawks due to an ankly injury, while the Panthres defense was torched 37 points and 425 yards. 

Place Your NFL Best Bets on the Vikings vs. Panthers Week 4 Matchup NOW!

The uncertainty over Young leads us to the Vikings and an experienced Kirk Cousins. Since Cousins came to Minnesota in 2018, the Vikings are 10-5-1 against the spread as road favorites, and we like that trend to continue against a struggling Panthers group. 

My Best Bet: Vikings -3.5 (-110) at BetMGM

Los Angeles Rams vs. Indianapolis Colts Week 4 NFL Picks

The Colts were able to overcome the loss of rookie quarterback Anthony Richardson and record a 22-19 overtime win over the Batlimore Ravens with Gardner Minshew. For the Rams, they've suffered two straight losses after an upset-win over the Seahawks in Week 1. This matchup could come down to who starts at quarterback for the Colts and is worth monitoring through the week. 

Place Your NFL Picks on the Rams vs. Colts Week 4 Matchup NOW!

As it stands, we're going to go with the Rams. Matthew Stafford and Aaron Donald proved this Rams group is still competitive, falling 19-16 to the Cincinnati Bengals on Monday night. We've seen two solid defensive performances out of the Rams this season and another could be in store given the Colts quarterback situation. 

My Best Bet: Rams +1 (-110) FanDuel

Tampa Bay Buccaneers vs. New Orleans Saints Week 4 NFL Picks

This is a direct fade of the possibility of Jameis Winston starting at quarterback for the Saints. In the Week 2 loss to the Packers, Derek Carr left the game after he was sacked and the team leading 17-0. Carr's injury allowed the Packers to rally and record an 18-17 victory. With Winston at quarterback, the Saints punted on their next four possessions and then missed what would have been the game-winning field goal. 

Place Your NFL Best Bets on the Buccaneers vs. Saints Week 4 Matchup NOW!

Tampa Bay didn't have much going for it in the 25-11 loss to the Philadelphia Eagles, but this is an ideal get-right spot for Tampa Bay if it ends up facing Winston. New Orleans offensive struggles were evident without Carr, and any bet on the Saints shouldn't be made unless it's clear Carr will be playing.

My Best Bet: Buccanneers +3 (-110) at Caesars

Washington Commanders at Philadelphia Eagles Week 4 NFL Picks

It was a methodical display of dominance from the Philadelphia Eagles in their 25-11 win over the Tampa Bay Buccaneers. Philly ran for 201 yards and averaged 5 yards per carry while forcing two turnovers and coming up with two sacks while pressuring Baker Mayfield throughout the night. Philadelphia will now face a Commanders team that was blown out 37-3 by the Buffalo Bills.

Place Your NFL Best Bets on the Commanders vs. Eagles Week 4 Matchup NOW!

We like the under in this matchup. Washington's struggling offense had just 230 yards against the Bills and committed five turnovers. Look for Philadelphia to control the clock on the ground while limiting Washington's scoring opportunities, which should lend this game to staying under the total. 

My Best Bet: Under 44.5 at bet365

Cincinnati Bengals vs. Tennessee Titans Week 4 NFL Picks

The Bengals and Titans are two teams still struggling on offense. Tenneessee scored just three points in the loss to the Browns and had just 94 yards of offense. Ryan Tannehill has been one of the worst quarterbacks in the league to start the season and has just 548 yards, one touchdown and three interpcetions in three games this season. 

Place Your NFL Best Bets on the Bengals vs. Titans Week 4 Matchup NOW!

Meanwhile, Cincinnatti has struggled to start the season and the 19-16 win over the Rams on Monday night didn't do much to dispel the concerns about the offense. Joe Burrow threw for 259 yards but continues to nurse a calf injury that has hindered him early on this season. There was also the season-debut against the Browns where the Bengals scored just three points. 

Considering each team's offensive struggles, we like the under in this one. 

My Best Bet: Under 41 (-110) at BetMGM

Las Vegas Raiders vs. Los Angeles Chargers Week 4 NFL Picks

Offense has not been an issue for the Chargers in the early parts of the season. Los Angeles is fifth in the league in points per game, averaging 28.7 per contest. The Chargers are coming off a 28-24 victory over the Minnesota Vikings after the defense came up clutch with a red zone stop to secure the victory. 

Place Your NFL Best Bets on the Raiders vs. Chargers Week 4 Matchup NOW!

Given how strong the Chargers have been on offense this season, we're going to back Los Angeles. The Raiders struggled last week against Pittsburgh, taking four sacks and turning it over three times. Those type of mistakes can't be made against an offense as efficient as the Chargers.

My Best Bet: Chargers -5.5 at FanDuel

New England Patriots vs. Dallas Cowboys Week 4 NFL Picks

The last two Patriots games have comfortably gone under the total, including the 15-10 win over the New York Jets. Meanwhile, Dallas' own offense struggled in the 28-16 loss to the Arizona Cardinals with the Cowboys struggling to finish drives. 

Place Your NFL Picks on the Patriots vs. Cowboys Week 4 Matchup NOW!

New England's blueprint against New York is how we project this game playing out. Look for the Patriots to control the clock and lean on its defense, knowing it will unlikely be able to match Dallas' offensive firepower. The Patriots tried this against the Dolphins in Week 2 and it resulted in that game going under the total, finishing 24-17. We expect a similar score this week between the Patriots and Cowboys.

My Best Bet: Under 43 (-110) at Caesars

Arizona Cardinals vs. San Francisco 49ers Week 4 NFL Picks & Odds

It's hard to see how Arizona can keep this one close. The 49ers are coming off an extended break after having played on Thursday in Week 3 against the New York Giants and have dominated the Steelers 30-7 and the Giants 30-12. If it wasn't for a meaningless, last-second field goal against the Rams, the 49ers would also be 3-0 against the spread to match their overall 3-0 record. 

Place Your NFL Best Bets on the Cardinals vs. 49ers Week 4 Matchup NOW!

The chance for a letdown spot for the 49ers also went out the window with the Cardinals upsetting the Cowboys, putting the 49ers on full alert. San Francisco has already shut down two inexperienced quarterbacks this season and we expect more of the same when it goes against Arizona's Josh Dobbs. 

This is a large spread, but given the offensive and defensive advantages, it's hard to see how Arizona keeps this close.

My Best Bet: 49ers -14 (-110) at bet365

Kansas City Chiefs vs. New York Jets Week 4 NFL Picks & Odds

The Zach Wilson run at quarterback is not going well once again for the New York Jets. Offensive players are getting into arguments on the sideline. Joe Namath is mentioning in the public how he's seen enough of Wilson. And the offense can't generate any sort of consistent production. The Jets managed just 171 yards in the loss to the Patriots, and Wilson took three sacks as the run game only generated 38 yards on 22 carries. 

Place Your NFL Best Bets on the Chiefs vs. Jets Week 4 Matchup NOW!

All of this is to say the Jets aren't in a place to compete with the defending Super Bowl champions. The Chiefs looked like their dominant selves against Chicago, leading 34-0 at halftime before eventually winning 41-10. Kansas City is back to beating up on bad teams, and this has the makings of another rout. 

My Best Bet: Chiefs -9.5 (-110) at BetMGM

Seattle Seahawks vs. New York Giants Week 4 NFL Picks

Since the Week 1 struggles to the Los Angeles Rams, the Seattle Seahawks have returned to the explosive unit many were projecting this season. Seattle upset the Lions in Detroit with a 37-31 overtime victory in Week 2 before following it up with another solid win, beating the Carolina Panthers 37-27 on Sunday. Geno Smith has played well for Seattle as of late, throwing for 328 yards against the Lions with two touchdowns and adding 296 yards and a score versus Carolina.

Place Your NFL Best Bets on the Seahawks vs. Giants Week 4 Matchup NOW!

Besides the second half against the Cardinals, the Gaints have been pretty bad through three weeks. New York outscored the Cardinals 31-8 in the second half to record the comeback win but has been outscored 90-12 in the other five halves combined. It's just hard to want to back New York considering how bad the team has looked for the majority of the season. 

My Best Bet: Seahawks +1.5 (-110) at FanDuel

Final Words on the NFL Week 4 Predictions & NFL Best Bets Today

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As we look forward to the thrilling NFL Week 1 matchups for today, there's another exciting development on the horizon for sports betting enthusiasts. Come this September, Kentucky will be launching online sports betting, paving the way for the emergence of new sports betting apps in Kentucky. This opens up a new realm of opportunities for fans and bettors alike. Stay tuned for more updates on this front.


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