NFL Predictions for Week 6: Odds & NFL Picks for All Games This Weekend

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NFL Picks & NFL Best Bets for Week 6

The NFL regular season continues with Week 6 as teams attempt to position themselves at the top of the standings. We're breaking down every game to give you the best totals, player props and sides for Week 6 of the NFL regular season. keep reading to see who we are confident in backing.

To get you ready for the NFL betting season, we’re providing you with some of our NFL best bets and picks. We’re also providing showing you the new sportsbook promotions, best bets and bonuses offered by our top sportsbooks featured on this page. Take advantage of these bonus bets and generous bonuses to help you solidify your NFL betting bankroll.

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Read our detailed analysis and NFL betting picks, giving you the information necessary to make valuable bets and have a fun viewing experience. If you are also looking to explore some parlays, visit our expert NFL picks and parlays options for Week 6.

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Denver Broncos vs. Kansas City Chiefs NFL Picks & Odds

Date: Thursday, Oct. 12, 2023, 8:15 p.m.
TV: Amazon Prime
My Best Bet: Isiah Pacheco Anytime Touchdown Scorer (-140) at FanDuel

Thursday's matchup features the Kansas City Chiefs taking on the Denver Broncos is a matchup that doesn't appear to be close on paper. The Chiefs are 4-1 and -10.5-point favorites, while the struggles for Denver continue at 1-4 this season. But instead of picking a side for this game, we're going to go with an anytime touchdown prop for our best bet in this matchup

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We like Isiah Pacheco Anytime Touchdown Scorer (-140) at FanDuel. Pacheco has scored a touchdown in each of his last three games and will now get a Broncos defense that struggles to stop the run. Denver gave up 234 rushing yards to the Jets in the 31-21 loss, including a 72-yard touchdown run by Breece Hall, who finished with 177 yards on 22 carries.

Just three weeks ago, the Broncos gave up 350 yards rushing and five touchdowns to the Miami Dolphins in the historically-bad 70-20 loss. Given the Broncos' issues stopping the run, we'll take Pacheco to get in the end zone at least once.

⭐ My Best Bet: Isiah Pacheco Anytime Touchdown Scorer (-140) at FanDuel

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Baltimore Ravens vs. Tennessee Titans NFL Picks & Odds

Date: Sunday, Oct. 15, 2023, 9:30 a.m.
TV: NFL Network
My Best Bet: Ravens -4 (-110) at BetMGM

Both the Ravens and Titans will look to bounce back following losses last week, with Baltimore losing on a late touchdown by the Pittsburgh Steelers after the Ravens controlled much of the game. Meanwhile, the Titans couldn't generate much offense in the 23-16 loss to the Indianapolis Colts.

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But the Ravens' issues have been more self-inflicted and what we feel can be easily remedied. Baltimore had seven drops against the Steelers, resulting in a lot of missed scoring opportunities. It was the third-most by a team since 2013 and the most since Week 6 of the 2021 season. The Ravens had just three drops in their first four games, meaning Sunday was an anomaly.

But the Titans' offensive issues go deeper than just drops. Tennessee ranks 26th in points per game at 17.6 and is 24th in yards per game (293). The Titans have not been able to run the ball as efficiently behind Derrick Henry with the team just 18th in rushing yards per contest (106.5). Ryan Tannehill has also been bad at quarterback with Tennessee's pass offense ranked 28th in pass yards per contest (187).

⭐ My Best Bet: Ravens -4 (-110) at BetMGM

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Washington Commanders vs. Atlanta Falcons NFL Picks & Odds

Date: Sunday, Oct. 15, 2023, 1:00 p.m. EDT
TV: CBS
My Best Bet: Falcons -2.5 (-110) at BetMGM

The Washington Commanders have extreme pass protection issues. In the 40-20 loss to the Chicago Bears, Sam Howell was sacked five times. The Washington quarterback has now been sacked 29 times this season, which puts him on pace for 99 sacks, which would break David Carr's record of 76 sacks in 2002.

Given Washington's pass protection issues and how the Commanders just gave up 451 yards of offense to the previously winless Bears, we're going to back Atlanta. Desmond Ridder had his best game as a starting quarterback, completing 28 of 37 passes for 329 yards and a touchdown.

⭐ My Best Bet: Falcons -2.5 (-110) at BetMGM

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Seattle Seahawks vs. Cincinnati Bengals NFL Week 6 Predictions

Date: Sunday, Oct. 15, 2023, 1:00 p.m. EDT
TV: CBS
My Best Bet: Seahawks +3 (-110) FanDuel

Joe Burrow and the Cincinnati offense finally returned to form last week in the 34-20 win over the Arizona Cardinals. Burrow threw for 317 yards and three touchdowns, while Ja'Marr Chase caught 15 passes for 192 yards and three scores. Despite that strong showing, it came against the lowly Cardinals, so we're not ready to pronounce the Bengals as fully back yet.

The Seahawks have the advantage of coming off the bye and have been more of a consistent offense this season. Seattle averages 27.8 points per game, the sixth-highest total in the league and is fourth in points per play at 0.472. The Seahawks also own the best rush defense in the league, giving up a league-low 3.2 yards per rush.

⭐ My Best Bet: Seahawks +3 (-110) FanDuel

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⭐ Place Your NFL Best Bets on the Colts vs. Jaguars Week 6 Matchup NOW! ⭐

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Indianapolis Colts vs. Jacksonville Jaguars Week 6 NFL Picks

Date: Sunday, Oct. 15, 2023, 1:00 p.m. EDT
TV: CBS
My Best Bet: Colts +4 (-110) at bet365

Sunday's Colts and Jaguars matchup is a key AFC South contest with both teams sitting atop the standings at 3-2. The Jaguars are coming off a 2-0 trip in London after beating the Falcons and Bills and now return to the United States to host the Colts.

Indianapolis will be without quarterback Anthony Richardson after he was placed on the injured reserve. But unlike other teams, the Colts have a capable backup in Gardner Minshew.

Minshew has come in relief in two games this season, which the Colts both won. He also started against the Ravens and led the team to a 22-19 win. The Colts also have one of the better run games in the league, averaging 131.2 yards per game, which ranks eighth in the league.

⭐ My Best Bet: Colts +4 (-110) at bet365

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Carolina Panthers vs. Miami Dolphins Week 6 NFL Picks

Date: Sunday, Oct. 15, 2023, 1:00 p.m. EDT
TV: CBS
My Best Bet: Dolphins -13.5 at BetMGM

There's no reason to take the Panthers in this matchup. Carolina has yet to cover a game this season and is 0-4-1 against the spread, with the only push coming on a backdoor touchdown and two-point conversion against the Saints.

The Panthers are 25th in points per game (18.2) and 30th in yards per play (4.40) and give up the 28th most points per contest at 28.8.

Now they have to go on the road to face a 4-1 Miami team that leads the league in scoring (36.2), yards (513.6) and points per play (0.586). This one could get ugly.

⭐ My Best Bet: Dolphins -13.5 at BetMGM

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Minnesota Vikings vs. Chicago Bears Week 6 NFL Picks

Date: Sunday, Oct. 15, 2023, 1:00 p.m. EDT
TV: CBS
My Best Bet: Vikings -2.5 (-110) FanDuel

The Vikings and Bears are two teams with bleak outlooks. Both teams are just 1-4, which is more surprising given the Vikings won the division last season with a 13-4 record. What's worse is Minnesota is set to place star wide receiver Justin Jefferson on the injured reserve.

At least the Bears can take solace in their first win in nearly a year after beating Washington 40-20 last week.

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But we're still going with the Vikings to cover considering the advantages they have over the Bears defense. Chicago's defense ranks 30th in points allowed per game (31.4) and is 29th in yards allowed (384.2) and is dead last in third-down defense, allowing opponents to convert at 57%.

The Vikings rank fourth in yards per play (5.9) and ninth in yards per game (362.4). We expect Minnesota to have success moving the ball against Chicago's defense.

⭐ My Best Bet: Vikings -2.5 (-110) FanDuel

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⭐ Place Your NFL Best Bets on the 49ers vs. Browns Week 6 Matchup NOW! ⭐

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San Francisco 49ers vs. Cleveland Browns Week 6 NFL Picks

Date: Sunday, Oct. 15, 2023, 1:00 p.m. EDT
TV: FOX
My Best Bet: 49ers -6.5 (-110) at Caesars

The main question surrounding the 49ers and Browns matchup is if Cleveland quarterback Deshaun Watson will play. He didn't practice on Monday and missed the Oct. 1 game against Baltimore. Watson hurt his shoulder on a running play versus the Titans two weeks ago and was limited in practice the following week before not playing.

We saw what Cleveland's offense is without Watson, with the Ravens winning 28-3. Watson's replacement, Dorian Thompson-Robinson threw for just 121 yards and had three interceptions. With Watson trending towards not playing, we would grab the -6.5 now in case he's ruled out. Even if he does play, we still like a 49ers team that is 4-1 against the spread and has yet to have a competitive game this season.

⭐ My Best Bet: 49ers -6.5 (-110) at Caesars

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New Orleans Saints vs. Houston Texans Week 6 NFL Picks

Date: Sunday, Oct. 15, 2023, 4:05 p.m. EDT
TV: FOX
My Best Bet: Under 42.5 (-110) at bet365

Both the Saints and Texans feature two of the better defenses in the league. Houston is 11th in points allowed per game (20), while New Orleans ranks fourth in the same category (15.2). The Saints are also fourth in yards allowed per game (274.6) and third in third-down defense (31%).

Given the two defenses, we're going to target the under. All five Saints games have gone under this season, while three of the five games for Houston have seen the under hit. These are two defensive-minded teams that have played to the under all season, so we're going to back that in this spot.

⭐ My Best Bet: Under 42.5 (-110) at bet365

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New England Patriots vs. Las Vegas Raiders Week 6 NFL Picks

Date: Sunday, Oct. 15, 2023, 4:05 p.m. EDT
TV: CBS
My Best Bet: Under 41.5 (-110) at BetMGM

New England's offense is abysmal. The Patriots rank last in points per game (11) and are just 26th in yards per game (287) and only convert 33% of third downs, ranking 28th in the league.

But the Raiders are no offensive juggernaut themselves, ranking 29th in points per game (15.8), yards per game (281.2) and third-down conversion (32%).

The best bet for these two teams is the under. Four of the five games for New England have seen the under hit, and it's the same for the Raiders with four of their games seeing the game go under the posted total.

⭐ My Best Bet: Under 41.5 (-110) at BetMGM

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Detroit Lions vs. Tampa Bay Buccaneers Week 6 NFL Picks

Date: Sunday, Oct. 15, 2023, 4:25 p.m. EDT
TV: FOX
My Best Bet: Buccaneers +3 (-110) at FanDuel

The Tampa Bay Buccaneers are coming off one of their best performances, beating the New Orleans Saints 26-9 in Week 4. Baker Mayfield passed for three touchdowns, and the Tampa Bay defense held the Saints to just 197 yards of offense and recorded three sacks and forced three turnovers.

Tampa's run defense could be key against a Lions offense that ranks fourth in run play percentage at 49.8%. The Buccaneers rank 10th in rush defense, allowing 94.8 rushing yards per game. One of the best characteristics of Tampa's defense is its takeaway rate. The Buccaneers are second in the league in takeaways per game at 2.5. There could be opportunities to turn over a Detroit team that averaged 1.4 turnovers per contest.

Tampa's defense should keep them in the game, and we'll gladly take the +3 for the home team coming off a bye.

⭐ My Best Bet: Buccaneers +3 (-110) at FanDuel

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Arizona Cardinals vs. Los Angeles Rams Week 6 NFL Picks

Date: Sunday, Oct. 15, 2023, 4:25 p.m. EDT
TV: CBS
My Best Bet: Rams -7 (-110) at Caesars

We finally saw what the Rams offense was capable with Cooper Kupp making his season debut last week against the Philadelphia Eagles. Kupp caught eight passes for 118 yards, while rookie Puka Nacua continued his strong season with seven catches and 71 yards. The Rams put up 14 first-half points before going scoreless in the second half.

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A solid passing game does not bode well for an Arizona defense that ranks 26th in passing yards allowed per game (251.4). The Cardinals allowed a previously dormant Cincinnati offense go off for 317 passing yards, and let Ja'Marr Chase catch 15 passes for 192 yards and three touchdowns.

We expect Kupp and the Rams to take advantage of the Cardinals' bad pass defense.

⭐ My Best Bet: Rams -7 (-110) at Caesars

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Philadelphia Eagles vs. New York Jets Week 6 NFL Picks & Odds

Date: Sunday, Oct. 15, 2023, 4:25 p.m. EDT
TV: FOX
My Best Bet: Under 41 (-110) at bet365

The Eagles and Jets are two of the stronger rushing teams in the league. Philadelphia leads the league in rush attempts per game (35.8) and rushing yards per game (164), while the Jets rank 11th in rushing yards per contest at 123.2 and sit third in yards per carry (5.4).

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Expect Philadelphia to exploit a bad Jets running defense, which ranks 29th in rushing yards allowed (146.2). This should result in longer, clock-draining drives which helps the under.

Meanwhile, the Eagles have one of the best run defenses in the league, ranking first in rushing yards allowed per game (61.2). It's hard to see how the Jets will move the ball. New York can't pass the ball with any consistency behind Zach Wilson. The Jets rank dead last in passing yards per game (160.4).

All signs point to a low-scoring game controlled by the Eagles.

⭐ My Best Bet: Under 41 (-110) at bet365

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New York Giants vs. Buffalo Bills NFL Picks & Odds

Date: Sunday, Oct. 15, 8:20 p.m. EDT
TV: NBC
My Best Bet: Bills -14 (-110) at BetMGM

The Giants continue to not be able to protect the quarterback. There was the Monday Night debacle against the Seahawks when New York allowed 11 sacks. Then, just last week the Giants surrendered seven sacks. It comes as no surprise the Giants have the highest sack percentage on quarterback dropbacks at 15.31%.

New York is 31st in points per game (12.4) and dead last in yards per game (255.2). This is a bad football team that's getting a bad matchup, on the road, against a Bills team coming off a loss in London to the Jaguars. Buffalo will be motivated to bounce back in primetime in front of its home crowd.

Also, Buffalo's defense ranks first in quarterback sack percentage at 12.50%. Everything points to trouble for New York.

⭐ My Best Bet: Bills -14 (-110) at BetMGM

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Dallas Cowboys vs. Los Angeles Chargers NFL Picks & Odds

Date: Monday, Oct. 16, 8:20 p.m. EDT
TV: ABC
My Best Bet: Over 51 (-110) at BetMGM

The Cowboys had a letdown on Sunday night against the 49ers, getting blown out 42-10. Now, Dallas will look to bounce back against a 2-2 Chargers team that's coming off a bye.

We're expecting plenty of points between these two high-scoring offenses. Dallas ranks eighth in points per game at 26.8 and is third in third-down conversion rate (49%). The Cowboys have one of the more efficient passing games, ranking seventh in completion percentage (69%).

Los Angeles ranks seventh in points per game at 27.5 and is fifth in yards per game (388.8) and fifth in yards per pass (7.4). But the Chargers don't defend the pass as well. Los Angeles ranks last in passing yards allowed per game (299.8), and given Dallas' high completion rate percentage, we expect the Cowboys to be able to move the ball through the air with regularity.

Given both the teams' strengths and the Chargers' weakness in the secondary, we expect a high-scoring game. Los Angeles running back Austin Ekeler is also expected to return after not playing since Week 1.

⭐ My Best Bet: Over 51 (-110) at BetMGM

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