San Francisco 49ers vs. LA Rams Predictions, Odds & NFL Picks for 09/17

Date IconLast Updated: Sep 17th, 2023
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San Francisco 49ers vs. LA Rams Predictions, Odds & NFL Picks for 09/17
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49ers vs. Rams Predictions & Best Bets Today: September 17, 2023


Both the San Francisco 49ers and Los Angeles Rams earned wins to start the NFL regular season and will now face off to see who will go 2-0. We're breaking down this key NFC West divisional matchup to give you our best bets and picks for this game and other NFL Week 2 contests. Check out what bets we are making in this game that we feel are a part of our best NFL Week 2 predictions.  

Make sure to keep reading to see who we're backing for the Week 1 games. We're also sharing our NFL best bets for the 2023-24 NFL season all year long, giving you insights into the thrilling outcomes to anticipate. Check out what bets we are making for Week 2 of the NFL regular season. 

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San Francisco 49ers vs. Los Angeles Rams Week 2 NFL Picks

Give the Los Angeles Rams credit for exceeding expectations and beating the Seattle Seahawks 30-13 as 4.5-point underdogs. Matthew Stafford was efficient in his return, completing 24 of 38 passes for 334 yards, while Kyren Williams added two rushing touchdowns. The Rams' defense held Seattle to just 180 yards of offense. 

Place Your NFL Best Bets on the 49ers vs. Rams Week 2 Matchup NOW!

But the Rams will now have to face a loaded 49ers team that looked downright dominant in the 30-7 win over the Steelers. Brock Purdy looked great in his return from arm surgery, throwing for 220 yards and two touchdowns, while Christian McCaffrey added 152 yards rushing and a 65-yard touchdown. The 49ers are still unbeaten when Purdy starts and finishes a game, and we like them to cover the large spread on the road. 

My Best Bet: 49ers -8 (-110) at BetMGM

San Francisco 49ers vs. Los Angeles Rams Week 2 NFL Picks

⭐ Christian McCaffery Over 66.5 Rushing Yards (-110) at FanDuel 

San Francisco 49ers running back Christian McCaffery was the dynamic runner we expected him to be in the Week 1 win over the Pittsburgh Steelers. McCaffery gained 152 yards, averaging 6.9 yards per carry, and had a highlight-reel-worthy 65-yard touchdown run to cap the afternoon. Given how explosive he looked after having a full offseason with the 49ers for the first time, we are going to target his player prop for Sunday's matchup against the Rams.  

We're going to go with McCaffery over 66.5 rushing yards (-110) at FanDuel. Dating back to last season, in McCaffery's last eight games with the 49ers, he has eclipsed this mark six times, including the 152-yard outing against the Steelers. During two games against the Rams last season, McCaffery went over this prop, including a 69-yard game as a member of the Carolina Panthers before getting traded to San Francisco and 94 yards against the Rams. 

We like McCaffery to duplicate his rushing success against Los Angeles once again. The Rams were average against the run versus Seattle, allowing 4.7 yards per carry. Look for another solid game on the ground from McCaffery. 

Best Betting Pick: Christian McCaffery Over 66.5 Rushing Yards (-110) at FanDuel


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As we look forward to the thrilling 2023 NFL season, there's another exciting development on the horizon for sports betting enthusiasts. Come this September, Kentucky will be launching online sports betting, paving the way for the emergence of new Kentucky betting apps. This opens up a new realm of opportunities for fans and bettors alike. Stay tuned for more updates on this front.


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