College Football Week 4 Predictions, Picks & Best College Football Bets

First Bet Safety Net up to $1,000
Promo Code: GAMBLING

Must be 21+ and present in OH. Gambling Problem? Call 1-800-GAMBLER

College Football Predictions for Week 4:

College football starts to see some top matchups in Week 4. There are several top-25 clashes, and CFB Picks spotlight a big game in South Bend, Indiana, on Saturday night. Besides that, we see what Oregon can do against Coach Prime and Colorado. Naturally, the best college football bets had that Iowa and Penn State Big-10 game ready to roll, too. While Nick Saban and the Crimson Tide are ready, no one knows how or if they will bounce back against Ole Miss.

Once more, the best online betting sites include BetMGM, FanDuel, Caesars, and DraftKings. Again, we preview all the potential carnage as either Ohio State or Notre Dame is going to escape Week 4 undefeated. Is this Notre Dame’s best chance to take down the Buckeyes? Let’s get to business and bring the heat with some College Football Week 4 predictions.

⭐ Grab Extra $1,500 and Place Your College Football Best Bets Today ⭐

Established 2001

Bet365 Sportsbook Bonus

⭐ Notre Dame Moneyline (+142) at FanDuel

Deposit required. Bonus Bets winnings are added to Bonus Bets balance. Bonus Bet wager excluded from returns. T&Cs, time limits and exclusions apply. Must be 21+ to participate. Gambling Problem? Call 1-800-GAMBLER

CFB Picks: Ohio State vs. Notre Dame Odds & CFB Predictions

The Ohio State Buckeyes and Notre Dame Fighting Irish rumble on Saturday night from South Bend, Indiana. This game is nationally televised on NBC and our prime choice for CFB Picks weekend. Ohio State comes in ranked sixth in the nation with wins against Indiana, Youngstown State, and Western Kentucky. Naturally, the quarterbacks get the spotlight. Kyle McCord has performed well, with six touchdowns through the air. However, the Buckeyes have not quite faced a team like Notre Dame and Sam Hartman.

Free college football picks love it when two top-ten teams get together. Ohio State has an almost two-thirds chance of winning, according to ESPN. However, our focus is on the moneyline and not the 3-point spread via FanDuel. Notre Dame at home is worth about a field goal alone, which makes the spread a little less attractive. The moneyline ranges from +130 to +142 and provides the value in the college football predictions today.

For the Ohio State vs. Notre Dame predictions, it is natural to look back at last year’s game, where the Buckeyes slugged their way to a 21-10 win. However, with Sam Hartman, Notre Dame has a balanced attack where they can score from anywhere. It is now put up or shut up time for the Irish. Audric Estime’s time is now, along with the Notre Dame defense. Even the Notre Dame first-half Moneyline is +112 at FanDuel and worth a look.

⭐ My best bet: Notre Dame Moneyline (+142) at FanDuel

⭐ Grab Extra $200 and Place Your College Football Best Bets Today ⭐

Established 2009

⭐ Colorado vs. Oregon: Over 70.5 Points (-110) at FanDuel

Must be 21+ and present in OH. Gambling Problem? Call 1-800-GAMBLER

CFB Picks: Colorado vs. Oregon Odds & CFB Predictions

Colorado and Oregon are one of those Pac-12 games where the calculator might break. Yes, college football predictions today see if anyone can slow either team down. The Oregon Ducks are capable of scoring 40+ points at any time, while Colorado has shown their mettle behind first-year coach Deion Sanders and quarterback Shedeur Sanders. Also, can the Buffaloes travel and play in a prime spot? Yes, Colorado was a three-score underdog against TCU, but Oregon is not TCU.

CFB Picks ponders the 21-point spread, and that has little value. This could be too close, and Deion Sanders will have his team ready to play in what could become another shootout like last week. Shedeur Sanders has 1251 yards passing and 11 combined touchdowns. Oregon’s Bo Nix has nearly 900 yards passing and eight touchdowns himself. Honestly, Colorado vs. Oregon predictions know the Ducks can bring the offense at home.

Oregon averages 58 points a game, while Colorado scored over 40 last week. A juicy number teetering near 70 via FanDuel represents a solid wager in our college football best bets.

⭐ My best bet: Colorado vs. Oregon: Over 70.5 Points (-110) at FanDuel

⭐ Grab Extra $200 and Place Your College Football Best Bets Today ⭐

Established 2009

⭐ Penn State -14.5 (-108) at DraftKings

Must be 21+ and present in OH. Gambling Problem? Call 1-800-GAMBLER

CFB Picks: Iowa vs. Penn State Odds & CFB Predictions

Iowa has scored points this season. Do not laugh. Watching 24th-ranked Iowa score 41 points was a shock. However, the reality may come on Saturday night against No. 7 Penn State on CBS. Free college football picks see if the Nittany Lions can gain a measure of revenge against the Hawkeyes. Iowa surprised Penn State two seasons ago and Coach James Franklin remembers that game well.

CFB picks wonder how Penn State will fare with such a large spread against a typically defensive-minded Iowa team. Again, the Nittany Lions struggled to cover a bit last week as they won 30-13 at Illinois. When it comes to the 14.5-point spread via DraftKings, there is a little value at -108. Most places are offering -110 or even -115.

The Nittany Lions' defense had four interceptions against Illinois while turning some of that defense into offense. Iowa vs. Penn State predictions believe that Penn State can control the line of scrimmage and pull away late. Expect the Nittany Lions to pull away and be one of our best college football bets for Week 4.

⭐ My best bet: Penn State -14.5 (-108) at DraftKings

⭐ Unlock up to $200 and Place Your College Football Best Bets Today ⭐

Established 2012

DraftKings Sportsbook Bonus

Bet $5, Get $200 Instantly in Bonus Bets
+ Get a No Sweat NBA SGP Every Day of NBA Playoffs

$1,000 First Bet on Caesars
Promo Code: GAMBLING1000

Must be 21+ and in a legal betting state to participate. T&Cs apply. Gambling Problem? Call 1-800-GAMBLER

CFB Picks: Ole Miss vs. Alabama Odds & CFB Predictions

⭐ Ole Miss +7 (-110) at Caesars

Ole Miss and Lane Kiffin come in like the student versus the teacher. Free college football picks look at if the Rebels can kick the Alabama Crimson Tide while they are down.

CFB picks take a calculated risk knowing that Nick Saban and Alabama have this game circled on the calendar. This is not the same Crimson Tide team. They allowed 34 points to Texas and only scored 17 last week. When it comes to a 7-point spread via Caesars, there is value for Ole Miss here.

The Ole Miss offense can pile up points and that is something that should scare Alabama. Ole Miss vs. Alabama predictions believe that the Rebels may even be capable of pulling off the upset (+222 Moneyline). The Rebels are one of our best college football bets for Week 4.

⭐ My best bet: Ole Miss +7 (-110) at Caesars

⭐ Unlock up to $1,000 and Place Your College Football Best Bets Today ⭐

Established 2013

Caesars Sportsbook Bonus

Must be 21+ and present in OH. New users and first wager only. Must register with eligible promo code. Maximum bet credit $1,000. Must be used within 14 days of receipt. See Caesars.com/promos for full terms. Void where prohibited. Know When To Stop Before You Start.® Gambling problem? Call 1-800-GAMBLER

Final Words on the College Football Best Bets Today

College Football Week 4 predictions expect some craziness from Saturday afternoon and then all night Saturday too. Penn State (-14.5 at DraftKings) is a solid choice to cover given their form and ability. For those doubting the Nittany Lions, remember that Penn State is motivated after losing to this Iowa team two seasons ago. Teams like Penn State remember well. The best online betting sites highlight these numbers well.

Finally, Alabama and Nick Saban are in the national spotlight at home. There figure to be nervous moments and the 7-point spread from Caesars figures to be something to consider for Saturday night. Texas’ Steve Sarkisian showed a way. Can Lane Kiffin follow the same path? At the least, this could be a Saturday afternoon nailbiter.

Simply, do not forget the game in Oregon. There will be many points in what should be the most-hyped 3:30 game of the weekend. Again, expect the unexpected. CFB picks are going to be fired up for this exciting college football weekend.

Don't miss the thrill! Learn how to claim the enticing bonus offer at FanDuel Sportsbook by exploring our detailed article. Additionally, we provide all the necessary details to get started with the bet365 sportsbook, enabling you to seize these two incredible welcome bonuses.

Established 2009