NY Giants vs. San Francisco 49ers NFL Week 3 Predictions & NFL Picks 09-21-23

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NY Giants vs. San Francisco 49ers NFL Week 3 Predictions & NFL Picks 09-21-23
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Giants vs. 49ers Predictions & Thursday Night Football Picks for 09/20


Week 3 of the NFL season brings a clash that has sports bettors scouring the best online betting sites for value. The New York Giants, fresh off a narrow win against the Arizona Cardinals, are set to face the undefeated San Francisco 49ers in a Thursday night showdown. The Giants, despite their recent win, have been inconsistent, as evidenced by their 1-1 record and a total of 40 first downs this season. On the other hand, the 49ers have been a force to reckon with, boasting a 2-0 record and accumulating 43 first downs.

For those looking for NFL Week 3 picks and predictions, the matchup is more than just numbers. The Giants have shown resilience but face a 49ers team that has been strong on both offense and defense. 

This Giants vs 49ers prediction will cover some in-depth analysis and information so that you can make informed NFL picks for Thursday Night Football betting action. Considering the 49ers' recent performance against the Rams and the Giants' comeback against the Cardinals, this game could go either way. The all-time series is tied at 21-21, making this game a must-watch for any NFL aficionado.


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Facing a short week, a struggling defense, the absence of Saquon Barkley, and a battered offensive line, the New York Giants' offense appears to have little opportunity for a positive outcome in their upcoming matchup. Let us dig a bit deeper and analyze the upcoming Thursday Night Football clash and check out our Giants vs. 49ers predictions:

How to Watch Giants vs. 49ers

  • Date: Thursday, September 21, 2023
  • Kick Off: 8:20 p.m. ET
  • Location: Levi Stadium, San Francisco, CA
  • Where to Watch: Amazon Prime or NBC

The Giants are in a precarious situation, especially with the absence of Saquon Barkley due to an ankle injury. Barkley accounted for a significant portion of the Giants' offense, and his absence puts them at a disadvantage. The Giants' defense has also been struggling, making them a 10-point road underdog against the 49ers, who boast one of the best defenses in the NFC.

Daniel Jones, the Giants' QB, has had a lackluster performance this season, and with injuries to the O-line, the 49ers' defense is expected to dominate. The Giants lost starting left guard Ben Bredson to a concussion and left tackle Andrew Thomas to a hamstring injury, further weakening their offensive line.

Key Players Missing:

  • Saquon Barkley (ankle)
  • Amari Cooper (groin)
  • Andrew Thomas (hamstring)

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On the other side, the 49ers are coming off a 30-23 win against the Rams. Their defense ranks third in EPA/play and has been excellent against the pass. They might be without Brandon Aiyuk due to a shoulder injury, but they have other weapons like Deebo Samuel and George Kittle to rely on. 

The 49ers are favorites with odds hitting as high as -10.5 with FanDuel. The Giants are expected to struggle, especially with their team total set at under 16.5 points according to FanDuel.

Key Players Missing

  • Brandon Aiyuk (shoulder; questionable)

NFL Week 3 Predictions: Giants vs. 49ers Odds, NFL Picks & NFL Best Bets

If the Giants replicate their sluggish start against the Cardinals, where they were down 20-0 at halftime, they'll find themselves out of the game before the third quarter against the 49ers. San Francisco boasts a well-rounded team capable of scoring while stifling opposing offenses. Their aggressive defense is likely to put significant pressure on Daniel Jones, who has already taken his fair share of hits this season. 

Without Saquon Barkley, the Giants lose their most potent weapon, making their uphill battle even steeper. Here are our NFL Week 3 predictions and picks for the Giants vs. 49ers Thursday Night Football clash:

⭐ NFL Pick 1: 49ers -10 ATS (-110) at BetMGM

The San Francisco 49ers are entering Week 3 with a strong 2-0 record, showcasing their balanced offense and stingy defense. They recently defeated the Rams 30-23, although they fell short of covering the line as a 7.5-point favorite. The 49ers' Brock Purdy has been efficient, throwing for 426 yards with two touchdowns and no interceptions so far. Given the Giants' shaky start to the season, the 49ers look poised to cover the -10 spread at BetMGM. This is a crucial factor in your NFL Week 3 Predictions.

⭐ NFL Pick 2: Over 44.5 total points (-110) at Caesars

The Giants managed to rally from a 20-0 halftime deficit to beat Arizona 31-28 in their last game. However, their defense has been porous, allowing an average of 34 points per game. On the other hand, the 49ers have been scoring an average of 30 points per game. Considering both teams' tendencies, the Over 44.5 total points at -110 odds with Caesars seems like a solid bet.

⭐ NFL Player Prop: Deebo Samuel Anytime TD Scorer (+110) at FanDuel

Deebo Samuel has been a versatile weapon for the 49ers, contributing both in the receiving and rushing game. He has 118 receiving yards and has also found the end zone as a rusher. Given the Giants' defensive struggles—they're last in the league in scoring defense, allowing an average of 34 points per game—Samuel is a good bet to score a touchdown at any time during the game, especially at +110 odds with FanDuel.

⭐ CLICK HERE and Check Out the FREE NFL Expert Picks for ALL 16 Games!!! ⭐ 


As we look forward to the thrilling 2023 NFL season, there's another exciting development on the horizon for sports betting enthusiasts. Come this September, Kentucky will be launching online sports betting, paving the way for the emergence of new Kentucky betting apps. This opens up a new realm of opportunities for fans and bettors alike. Stay tuned for more updates on this front.


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